73283-20-2

Basic information

• Product Name: 3-(2-chlorophenyl)-2-(3,3,3-trifluoro-2-oxopropyl)quinazolin-4(3H)-one
• CAS NO: 73283-20-2
• Molecular Formula: C₁₇H₁₀ClF₃N₂O₂
• Molecular Weight: 366.7217
• Mol File: 73283-20-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 461.4°C at 760 mmHg
• Flash Point: 232.8°C
• Density: 1.44g/cm³
• Vapor Pressure: 1.08E-08mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 3-(2-chlorophenyl)-2-(3,3,3-trifluoro-2-oxopropyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)-2-(3,3,3-trifluoro-2-oxopropyl)quinazolin-4(3H)-one(73283-20-2)
• EPA Substance Registry System: 3-(2-chlorophenyl)-2-(3,3,3-trifluoro-2-oxopropyl)quinazolin-4(3H)-one(73283-20-2)

Safety Data

• Hazardous Substances Data: 73283-20-2(Hazardous Substances Data)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 340-57-8 mecloqualone 

Relevant articles and documents

2-Ketoalkyl-4(3H)-quinazolinones

2-Ketoalkyl-4(3H)-quinazolinones of the formula STR1 wherein R1 is an aliphatic, cycloaliphatic or hydrocarbon aromatic group of 1-10 carbon atoms; A is divalent alkylene of 1 to 10 carbon atoms; R2 is an aliphatic, cycloaliphatic, hydrocarbon aromatic or heterocyclic group of 1-10 carbon atoms formed by condensing an acyl ester of the formula R2 COOR' which can be dissociated to form --COR2 and R'OH in which R' is the alcoholic portion of said ester; and R3 and R4 are each hydrogen, hydroxy, amino, halogen, trifluoromethyl, alkyl, alkoxy, alkylthio or alkylsulfonyl each of 1-4 carbon atoms, the substituents other than hydrogen when present being preferably in the 6- and/or 7-position of the quinazolinone nucleus provide compounds having useful activity as CNS depressants and anticonvulsants. A process is provided for preparing such compounds by ester condensation of a corresponding 2-alkyl-3-substituted-4(3H) quinazolinone with a condensable ester and excess sodium hydride in the presence of a strong ionization solvent such as refluxing 1,2-dimethoxyethane.