73354-52-6

Basic information

• Product Name: 1-Phenyl-3-(1-naphthyl)-2,3-epoxy-1-propanone
• Synonyms: 1-Phenyl-3-(1-naphthyl)-2,3-epoxy-1-propanone
• CAS NO: 73354-52-6
• Molecular Weight: 274.319
• Mol File: 73354-52-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Phenyl-3-(1-naphthyl)-2,3-epoxy-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-3-(1-naphthyl)-2,3-epoxy-1-propanone(73354-52-6)
• EPA Substance Registry System: 1-Phenyl-3-(1-naphthyl)-2,3-epoxy-1-propanone(73354-52-6)

Safety Data

• Hazardous Substances Data: 73354-52-6(Hazardous Substances Data)

Upstream product

• 80674-36-8 3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one 

Downstream Products

• 66-77-3 1-naphthaldehyde 
• 78498-88-1 1-Phenyl-3-(1-naphthyl)-1,2-propanedione 
• 73354-58-2 (3aR,4R,6R,6aS)-4-Benzoyl-6-naphthalen-1-yl-tetrahydro-furo[3,4-c]furan-1,3-dione 
• 84274-62-4 (2S,3S,4R,5S)-2-Benzoyl-5-naphthalen-1-yl-tetrahydro-furan-3,4-dicarboxylic acid dimethyl ester 
• 84253-29-2 (2R,3S)-2-Benzoyl-5-naphthalen-1-yl-2,3-dihydro-furan-3,4-dicarboxylic acid dimethyl ester 
• 84253-28-1 2-Benzoyl-5-naphthalen-1-yl-2,5-dihydro-furan-3,4-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Metal-free, one-pot, sequential protocol for transforming ,-epoxy ketones to -hydroxy ketones and -methylene ketones

A new sequential, one-pot protocol for transforming 1,3-disubstituted 2,3-epoxy ketones to β;-hydroxy ketones and α-methylene ketones has been developed. Reaction of epoxy ketones with boron trifluoride etherate (BF3·OEt2) generates the cationic intermediates by regioselective epoxide ring opening and an acyl shift. Then, a treatment of these cations with 2-aryl-1,3-dimethylbenzimidazolines (DMBIH) results in formation of 1,2-disubstituted 3-hydroxy ketones. DMBIH serves as a hydride donor in the second step of this process. Finally, the β;-hydroxy ketones can be converted to 1,2-disubstituted 2-methylene ketones by treatment with methanesulfonic acid or a combination of methanesulfonyl chloride and triethylamine. Importantly, the sequential steps involved in formation of the α-methylene ketone products can be carried out in one pot.

Method for preparing epoxide through induction of visible light

The invention belongs to the technical field of organic synthesis and provides a method for preparing an epoxide through induction of visible light. The method comprises the following step: under thecondition that the visible light and a photosensitizer exist, by taking oxygen or air as an oxygen source or an oxidizing agent and taking a synthesized amidine derivative as a catalyst, performing areaction at the temperature of -40-50 DEG C for 36h-192h, so that olefin is directly oxidized into the corresponding epoxide. The method is mild in reaction conditions, and the yield is as high as 94%or above, therefore, the method has good development value and application prospect.