733758-20-8 Usage
Chemical Class
Imidazopyridines
Common Use
Pharmaceutical intermediate in the synthesis of various medications
Potential Applications
Development of new drugs
Characteristic Features
Presence of a trifluoromethyl group and a fused imidazole and pyridine ring system
Chemical and Pharmacological Properties
Unique due to the structure and presence of the trifluoromethyl group and the fused ring system
Value in Medicinal Chemistry
Valuable building block due to its structure and reactivity, provides opportunities for the design and synthesis of novel pharmaceuticals with improved therapeutic properties
Specialized Structure
Allows for tailored modifications to target specific biological pathways or molecular targets, making it a versatile and valuable compound in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 733758-20-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,3,7,5 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 733758-20:
(8*7)+(7*3)+(6*3)+(5*7)+(4*5)+(3*8)+(2*2)+(1*0)=178
178 % 10 = 8
So 733758-20-8 is a valid CAS Registry Number.
733758-20-8Relevant articles and documents
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Chen, Ping,Caldwell, Charles G.,Mathvink, Robert J.,Leiting, Barbara,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,He, Huaibing,Lyons, Kathryn A.,Thornberry, Nancy A.,Weber, Ann E.
, p. 5853 - 5857 (2008/04/03)
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC50 values as low as 5.8 nM for inhibition of DPP-4.
