73384-27-7Relevant articles and documents
COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
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Page/Page column 172; 12/40, (2008/06/13)
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
Synthesis of Benzothiazoles. α-Amino-(4-hydroxy-6-benzothiazolyl)propionic Acid.
Ismail, Ibrahim A.,Sharp, Dale E.,Chedekel, Miles R.
, p. 2243 - 2246 (2007/10/02)
The tentative structure assigned to the photobiologically important skin pigment pheomelanin is based on degradative studies of the natural chromophore.The title compound was reported to be one of several key amino acids isolated in these studies.The identity of this benzothiazole derivative has now been confirmed via an unambiguous eight-step total synthesis starting from 5-methyl-2-nitrophenol.