73397-68-9

Basic information

• Product Name: 2-Hexanone, 1-hydroxy-
• CAS NO: 73397-68-9
• Molecular Formula: C6H12O2
• Molecular Weight: 116.16
• Mol File: 73397-68-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Hexanone, 1-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexanone, 1-hydroxy-(73397-68-9)
• EPA Substance Registry System: 2-Hexanone, 1-hydroxy-(73397-68-9)

Safety Data

• Hazardous Substances Data: 73397-68-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 591-78-6 n-hexan-2-one 
• 7433-56-9 (E)-5-decene 
• 78389-72-7 1-iodo-2-hexanone 

Downstream Products

• 20261-68-1 1-chlorohexan-2-one 
• 80696-29-3 (S)-(+)-2-Amino-1-hexanol 
• 1613415-72-7 (R)-4-butyl-4-(4-methoxyphenyl)-1,2,3-oxathiazolidine 2,2-dioxide 
• 5665-74-7 2-amino-1-hexanol 
• 86921-37-1 1-(2-Phenethyl)-2-methyl-4-n-butylimidazole 
• 5177-85-5 2-(2,4-dinitro-phenylhydrazono)-hexanal-(2,4-dinitro-phenylhydrazone) 
• 6920-22-5 Hexane-1,2-diol 

Relevant articles and documents

Synthesis of aggregation pheromone components of cerambycid species through α-hydroxylation of alkylketones

The synthesis of 3-hydroxy-2-hexanone and 2,3-hexanediol, two components of the aggregation pheromone of several cerambycid species, is disclosed in here. Starting from 2-hexanone, through an α-hydroxylation using (diacetoxyiodo)benzene, 3-hydroxy-2-hexanone is obtained in good yield. Further reduction of this compound, gives 2,3-hexanediol in excellent yield. A study of the α-hydroxylation reaction of several alkylketones using an hypervalent iodine reagent is also disclosed in here. The synthesis of optically active compounds (R)- and (S)-3-hydroxy-2-hexanone was achieved starting from 2-hexanone with nitrosobenzene and L- and D-proline respectively, in several reaction media.

Photo-irradiation of α-halo carbonyl compounds: A novel synthesis of α-hydroxy- and α,α′-dihydroxyketones

The reaction of α-halo ketones (α-iodocycloalkanones, α-bromocycloalkanones, α-iodo-β-alkoxy esters, and α-iodoacyclicketones) with irradiation under a high-pressure mercury lamp gave the corresponding α-hydroxyketones in good yields. For α-bromoketones, it was found that α-hydroxylation does not occur. However, α-bromoketones were converted into α-hydroxyketones in the presence of KI. In the case of α,α′-diiodo ketones, α,α′-dihydroxyketones, which up to now have scarcely been reported, were obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxy- and α,α′- dihydroxyketones.

Selectivity in the Oxidation of Aliphatic Ketones by Thallic Sulphate in Aqueous Medium

The effects of temperature, structure and sulphuric acid concentration on the selectivity of the oxidation of aliphatic ketones (R1COR2) (1a-g) by thallic sulphate have been investigated.With increasing temperature the quantity of internal α-hydroxyketone (3a-d) decreases and the quantity of 1-hydroxyketone (2a-d) increases in the oxidation of methyl alkyl ketone (R2>CH3) (1a-d).The same concerns to the oxidation products of hexan-3-one (1e): 2-hydroxy-hexan-3-one (2e) and 4-hydroxy-hexan-3-one (3e), respectively. "The inverse selectivity temperature" (IST) for oxidation of linear methyl alkyl ketones (1a-c) and hexan-3-one (1e) has been found.With the use of the linear free-energy relationship it has been found that the selectivity of the reaction decreases with increasing the polar and steric effects of substituents R1,R2.With increasing the sulphuric acid concentration the selctivity of the oxidation of methyl alkyl ketones (1a, 1d) increases.