734-18-9

Basic information

• Product Name: 2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethan-1-one
• Synonyms: 2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethan-1-one
• CAS NO: 734-18-9
• Molecular Weight: 296.294
• Mol File: 734-18-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethan-1-one(734-18-9)
• EPA Substance Registry System: 2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethan-1-one(734-18-9)

Safety Data

• Hazardous Substances Data: 734-18-9(Hazardous Substances Data)

Upstream product

• 3406-03-9 2-(phenylsulfonyl)acetophenone 
• 16222-10-9 1-phenyl-2-(phenylthio)ethanone 
• 108-98-5 thiophenol 
• 70-11-1 α-bromoacetophenone 
• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 86340-78-5 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene 
• 93-58-3 benzoic acid methyl ester 
• 1535-65-5 difluoromethyl phenyl sulfone 
• 677-67-8 fluorosulfonyldifluoroacetyl fluoride 
• 71-43-2 benzene 
• 6099-23-6 1-(phenylsulfinyl)acetophenone 

Downstream Products

• 86340-78-5 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene 
• 1151549-60-8 3,3-dichloro-1,1-difluoro-2-phenyl-1-(phenylsulfonyl)propan-2-ol 

Relevant articles and documents

Preparation method of alpha, alpha-difluoro-beta-ketone sulfone compound

The invention provides a preparation method of an alpha, alpha-difluoro-beta ketone sulfone compound, and belongs to the technical field of chemistry. The invention firstly provides a composition forpreparing a compound shown as a formula I, which consists of the following components: a compound 1, a fluoride initiator and an organic solvent; Ar1 and Ar2 are independently selected from a substituted or unsubstituted aryl group and a substituted or unsubstituted heteroatom aryl group respectively. The invention also provides a method for preparing alpha, alpha-difluoro-beta-ketone sulfone compounds from the composition. According to the invention, metal fluoride is used as an initiator, and a series of compounds can be prepared under mild conditions. The preparation method is simple in synthetic route, good in yield and high in purity; the method has the advantages of excellent functional group adaptability and the like, can be used for preparing alpha, alpha-difluoro-beta-ketone sulfone compounds with various functional groups, and is successfully applied to later modification of natural products and drug molecules. Besides, the reaction scale of the method can be amplified to gram level, and the method can be used for industrial amplification production and has a good application prospect.

Photoredox-catalyzed sulfonylation of difluoroenoxysilanes with the insertion of sulfur dioxide

A photoredox-catalyzed three-component reaction of aryldiazonium tetrafluoroborates with sodium metabisulfite and 2,2-difluoro enol silyl ethers is described. By using sodium metabisulfite as the source of sulfur dioxide, this method provides an elegant a

Stereoselective [3+2] cycloaddition of N-tert-butanesulfinyl imines to arynes facilitated by a removable PhSO2CF2 group: Synthesis and transformation of cyclic sulfoximines

An unprecedented [3+2] cycloaddition between N-tert-butanesulfinyl imines and arynes provides a stereoselective method for the synthesis of cyclic sulfoximines. Not only does the difluoro(phenylsulfonyl)methyl group play an important role in facilitating the cycloaddition reaction, it can also be removed or substituted through the transformation of the difluorinated cyclic sulfoximines to cyclic sulfinamides. This journal is the Partner Organisations 2014.