7340-34-3

Basic information

• Product Name: 4-Pyridinepropenoic acid methyl ester
• Synonyms: 4-Pyridinepropenoic acid methyl ester;4-Pyridineacrylic acid, methyl ester;Acrylic acid, 3-(4-pyridyl)-, methyl ester;Methyl-beta-(4-pyridyl)-acrylate;Nsc 84239;2-Propenoic acid, 3-(4-pyridinyl)-, Methyl ester;Methyl 3-(pyridin-4-yl)acrylate;3-(4-pyridinyl)-2-Propenoic acid methyl ester
• CAS NO: 7340-34-3
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.17
• Mol File: 7340-34-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 277.8°C at 760 mmHg
• Flash Point: 121.8°C
• Appearance: /
• Density: 1.136g/cm³
• Vapor Pressure: 0.00443mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Pyridinepropenoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinepropenoic acid methyl ester(7340-34-3)
• EPA Substance Registry System: 4-Pyridinepropenoic acid methyl ester(7340-34-3)

Safety Data

• Hazardous Substances Data: 7340-34-3(Hazardous Substances Data)

Usage

General Description

4-Pyridinepropenoic acid methyl ester, also known as methyl 4-pyridylacrylate, is a chemical compound with the molecular formula C8H7NO2. It is a colorless to pale yellow liquid with a strong odor. This chemical is used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of flavor and fragrance compounds. 4-Pyridinepropenoic acid methyl ester is also used as an intermediate in the manufacturing of other organic compounds. It has potential environmental and health hazards and should be handled with care and according to safety guidelines.

InChI:InChI=1/C9H9NO2/c1-12-9(11)3-2-8-4-6-10-7-5-8/h2-7H,1H3/b3-2+

Upstream product

• 84228-93-3 3-(pyridin-4-yl)acrylic acid 
• 872-85-5 pyridine-4-carbaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 1120-87-2 4-bromopyridin 
• 292638-85-8 acrylic acid methyl ester 
• 67-56-1 methanol 
• 5337-79-1 3-(4-pyridinyl)-2-propenoic acid 
• 1529-78-8 [(methoxycarbonyl)methyl]triphenylarsonium bromide 
• 1067-74-9 Methyl diethylphosphonoacetate 
• 5927-18-4 trimethyl phosphonoacetate 

Downstream Products

• 84228-93-3 3-(pyridin-4-yl)acrylic acid 
• 90610-07-4 4-pyridinepropanoic acid methyl ester 
• 120690-80-4 3-(pyridin-4-yl)propionaldehyde 
• 1360966-54-6 C₆H₅FO₂*C₁₈H₁₈N₂O₄ 

Relevant articles and documents

Uranyl-Organic Coordination Compounds Incorporating Photoactive Vinylpyridine Moieties: Synthesis, Structural Characterization, and Light-Induced Fluorescence Attenuation

The fluorescence of uranyl originated from electronic transitions (S11-S00 and S10-S0v, v = 0-4) of the ligand-to-metal charge transfer (LMCT) process is an intrinsic property of many uranyl coordination compounds. However, light-induced regulation on fluorescence features of uranyl hybrid materials through photoactive functional groups is less investigated. In this work, the photoactive vinyl group-containing ligands, (E)-methyl 3-(pyridin-4-yl)acrylate and (E)-methyl 3-(pyridin-3-yl)acrylate, have been used in the construction of uranyl coordination polymers in the presence of 1,10-phenanthroline (phen). Five compounds (UO2)3(μ3-O)(μ2-OH)2(L1)2(phen)2(1), (UO2)3(μ3-O)(μ2-OH)3(L1)(phen)2 (2), (UO2)3(μ3-O)(μ2-OH)3(L2)(phen)2 (3), [(UO2)2(μ2-OH)2(L2)2(phen)2]·2H2O (4), and (UO2)Zn(SO4)(phen)(H2O)(OH)2(5) were obtained under hydrothermal conditions. Compounds 1-4 are polynuclear uranyl structures with abundant π-π interactions and hydrogen bonds contributed to the 3D crystal packing of them. As model compounds, 1 and 3 are selected for exploring photoresponsive behaviors. The emission intensities of these two compounds are found to decrease gradually over the exposure time of UV irradiation. X-ray single crystal structural analysis suggests that the fluorescence attenuation can be explained by the slight rotation of pyridinyl groups around the carbon-carbon double bond during UV irradiation, which is accompanied by the change of weak interactions, i.e., π-π interactions and hydrogen bonds in strength and density. This feature of light-induced fluorescence attenuation may enable these two compounds to act as potential photoresponsive sensor materials.

Synthesis of olefins via a Wittig reaction mediated by triphenylarsine

An arsine-mediated Wittig reaction for the synthesis of olefins is described. After heating triphenylarsine in the presence of an activated alkyl bromide for 30?min, the resulting arsonium salt condensed with aldehydes in as little as 5?min at room temperature, yielding the olefins in high yields. Aromatic, heteroaromatic, and alkyl aldehydes were all suitable substrates for this process.

NRF2 REGULATORS

The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.