73438-28-5Relevant articles and documents
Synthesis and in vitro pharmacological evaluation of novel 2-hydroxypropyl-4-arylpiperazine derivatives as serotoninergic ligands
Fiorino, Ferdinando,Magli, Elisa,Severino, Beatrice,Corvino, Angela,Ciano, Antonio,Perissutti, Elisa,Frecentese, Francesco,Massarelli, Paola,Nencini, Cristina,Santagada, Vincenzo,Caliendo, Giuseppe
, p. 698 - 706 (2016/03/01)
This paper reports the synthesis of new norbornene and exo-N-hydroxy-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide derivatives and their binding to the 5-HT1A, 5-HT2A, and 5-HT2C receptors, in order to identify selective
Investigations on the synthesis and pharmacological properties of 4-alkoxy-2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl]-6-methyl-1H-pyrrolo [3,4-c]pyridine-1,3(2H)-diones
Sladowska, Helena,Filipek, Barbara,Szkatula, Dominika,Sabiniarz, Aleksandra,Kardasz, Malgorzata,Potoczek, Joanna,Sieklucka-Dziuba, Maria,Rajtar, Grazyna,Kleinrok, Zdzislaw,Lis, Tadeusz
, p. 897 - 908 (2007/10/03)
Synthesis of 2-[2-hydroxy-3-(4-aryl-1-piperazinyl)propyl] derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones (8-12) is described. The chlorides used in the above synthesis can exist in two isomeric forms: chain (18-20) and cyclic (19a, 20a). The compounds 8-12 exhibited potent analgesic activity which was superior than that of acetylsalicylic acid in two different tests. Most of the investigated imides suppressed significantly spontaneous locomotor activity in mice.
