73452-52-5

Basic information

• Product Name: N-hydroxy-P,P-diphenylphosphinic amide
• CAS NO: 73452-52-5
• Molecular Formula: C₁₂H₁₂NO₂P
• Molecular Weight: 233.2029
• Mol File: 73452-52-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 396°C at 760 mmHg
• Flash Point: 193.3°C
• Density: 1.28g/cm³
• Vapor Pressure: 5.56E-07mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: N-hydroxy-P,P-diphenylphosphinic amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxy-P,P-diphenylphosphinic amide(73452-52-5)
• EPA Substance Registry System: N-hydroxy-P,P-diphenylphosphinic amide(73452-52-5)

Safety Data

• Hazardous Substances Data: 73452-52-5(Hazardous Substances Data)

Upstream product

• 1499-21-4 Diphenylphosphinic chloride 
• 1079-66-9 chloro-diphenylphosphine 

Downstream Products

• 237752-48-6 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide 
• 554412-98-5 3-Oxa-tricyclo[3.2.2.02,4]nonane-2-carboxylic acid N-(4-nitro-3-trifluoromethyl-phenyl)-hydrazide 
• 84718-88-7 n-diphenylphosphinyldimethylsulphilimine 
• 38938-31-7 methyl N,P-diphenylphosphonamidate 
• 1707-03-5 diphenyl-phosphinic acid 
• 1706-90-7 methyl diphenylphosphinate 
• 193346-78-0 C₂₆H₂₅NO₃P₂ 
• 237752-47-5 3-(diphenyl-phosphinoyl)-2-oxa-3-aza-bicyclo[2.2.1]hept-5-ene 
• 73452-25-2 tert-butylammonium N,P-diphenylphosphonamidate 

Relevant articles and documents

Preparation and Characterisation of N-(Diphenylphosphinoyl)hydroxylamine, and Conversion into O-Sulphonyl Derivatives that undergo Lossen-like Rearrangement

Having previously shown that diphenylphosphinic chloride (1a) forms O-(diphenylphosphinoyl)hydroxylamine (3a) with hydroxylamine, we have now established that N-(diphenylphosphinoyl)hydroxylamine (2a) can be obtained in good yield by reaction of (1a) with O-trimethylsilylhydroxylamine followed by methanolytic removal of the silyl blocking group.The di-p-tolyl (2b) and bis-p-methoxyphenyl (2c) analogues can be prepared in a similar way.N-(Diphenylphosphinoyl)hydroxylamine is acetylated at the O atom with acetic anhydride, and is sulphonylated at O with methanesulphonyl chloride and toluene-p-sulphonyl chloride.The N-(diphenylphosphinoyl)-O-sulphonylhydroxylamines (8) and (12a) undergo rapid and quantitative Lossen-like rearrangement with methanol-sodium methoxide to give methyl N,P-diphenylphosphonamidate (11).Comparable rearrangement are observed with t-butylamine, aniline-triethylamine, and phenol-triethylamine.