73544-70-4

Basic information

• Product Name: 2-Benzothiazolemethanethiol(6CI,9CI)
• Synonyms: 2-Benzothiazolemethanethiol(6CI,9CI)
• CAS NO: 73544-70-4
• Molecular Formula: C₈H₇NS₂
• Molecular Weight: 181.27788
• Product Categories: BENZOTHIAZOLE
• Mol File: 73544-70-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Benzothiazolemethanethiol(6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolemethanethiol(6CI,9CI)(73544-70-4)
• EPA Substance Registry System: 2-Benzothiazolemethanethiol(6CI,9CI)(73544-70-4)

Safety Data

• Hazardous Substances Data: 73544-70-4(Hazardous Substances Data)

Upstream product

• 106086-78-6 2-(bromomethyl)-1,3-benzothiazole 
• 37859-43-1 2-chloromethylbenzothiazole 

Downstream Products

• 110704-30-8 C₈H₆ClNS₂ 

Relevant articles and documents

Preparation methods of 2-[(2-benzothiazolylmethyl)thio]-6-ethoxybenzothiazole and intermediates thereof

The invention provides a preparation method of 2-[(2-benzothiazolylmethyl)thio]-6-ethoxybenzothiazole. The method includes reacting a compound (II) and a compound (III) in a solvent under an alkalinecondition with or without a catalyst to obtain a compound (I) that is the 2-[(2-benzothiazolylmethyl)thio]-6-ethoxybenzothiazole. The invention further provides a preparation method of the compound (II), including reacting a compound (IV) with a nitrosation agent and a copper agent in order in a solvent. The invention further provides a preparation method of the compound (III), including reactinga compound (V) with a sulfurizing agent in a solvent to obtain the compound (III). According to the methods, raw materials are cheap and easily available or easy to prepare, reaction conditions are mild, and selectivity and yields are high. The intermediates and a product are purified through crystallization instead of column chromatography and the methods are suitable for industrialization.

Substituted organosulfur compounds and methods of using thereof

The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.

Synthesis and Biological Activity of trans-(+/-)-N-Methyl-2-(3-pirydyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

The synthesis and biological activity of trans-(+/-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (8a, RP 49356) and analoques is reported.These compounds constitute a new structural class of K+-channel opener.The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed.A 3-pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in which the sulfoxide is in a trans relationship to thioamide, are preferred for activity.Selected compounds were tested intravenously in the normotensive anaesthetized rat for hypotensive effects, and the activities reflect their in vitro K+-channel opening activity.This led to further evaluation of compound 8a and the selection of the (-)-enantiomer 8b (RP 52891) for development as an antihypertensive and antianginal agent.