73554-61-7

Basic information

• Product Name: 1-(3,4,5-trimethoxy-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline
• CAS NO: 73554-61-7
• Molecular Weight: 352.433
• Mol File: 73554-61-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,4,5-trimethoxy-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4,5-trimethoxy-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline(73554-61-7)
• EPA Substance Registry System: 1-(3,4,5-trimethoxy-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline(73554-61-7)

Safety Data

• Hazardous Substances Data: 73554-61-7(Hazardous Substances Data)

Upstream product

• 92249-24-6 2-methyl-4-(3,4,5-trimethoxyphenylmethylene)-5(4H)-oxazolone 
• 61404-52-2 3-(3,4,5-trimethoxyphenyl)pyruvic acid 
• 343-94-2 tryptamine hydochloride 
• 5320-31-0 3,4,5-trimethoxyphenylacetaldehyde 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Relevant articles and documents

Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5HT(2B)) contractile receptor in the rat stomach fundus

A series of potent, selective 5HT(2B) receptor antagonists has been identified based upon yohimbine, with SAR studies resulting in a 1000-fold increase in 5HT(2B) receptor affinity relative to the starting structure (- log K(B)s > 10.0 have been obtained). These high-affinity tetrahydro-β- carboline antagonists are able to discriminate among the 5HT2 family of serotonin receptors, with members of the series showing selectivities of more than 100-fold versus both the 5HT(2A) and 5HT(2C) receptors based upon radioligand binding and functional assays. As the first compounds reported with such selectivity and enhanced receptor affinity, these tetrahydro-β- carboline antagonists are useful tools for elucidating the role of serotonin acting at the 5HT(2B) receptor in normal and disease physiology.