73604-32-7

Basic information

• Product Name: L-α-hydroxyisocaproyl-Leu-Val-Phe-OCH3
• CAS NO: 73604-32-7
• Molecular Weight: 505.655
• Mol File: 73604-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-α-hydroxyisocaproyl-Leu-Val-Phe-OCH3(CAS DataBase Reference)
• NIST Chemistry Reference: L-α-hydroxyisocaproyl-Leu-Val-Phe-OCH3(73604-32-7)
• EPA Substance Registry System: L-α-hydroxyisocaproyl-Leu-Val-Phe-OCH3(73604-32-7)

Safety Data

• Hazardous Substances Data: 73604-32-7(Hazardous Substances Data)

Upstream product

• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 73604-37-2 Leu-Val-Phe-OCH₃*HCl 
• 13748-90-8 (S)-2-hydroxyl-3,3-dimethylbutyric acid 
• 73604-36-1 Z-Leu-Val-Phe-OCH₃ 
• 2018-66-8 Z-Leu-OH 
• 328-38-1 (R)-leucine 
• 10342-47-9 L-valine-L-phenylalanine methyl ester hydrochloride 

Relevant articles and documents

N-(α-Hydroxyalkanoyl) Derivatives of Leu-Val-Phe-OCH3 as Inhibitors of Renin

The following N-(α-hydroxyalkanoyl) derivatives of Leu-Val-Phe-OCH3 were synthesized and tested for their ability to inhibit human amniotic renin: D- and L-α-hydroxyisocaproyl-Leu-Val-Phe-OCH3, D- and L-α-hydroxyisovaleryl-Leu-Val-Phe-OCH3, L-2-hydroxy-3-phenylpropanoyl-Leu-Val-Phe-OCH3, and D- and L-α-hydroxyphenylacetyl-Leu-Val-Phe-OCH3.Analysis of the compounds through the use of Dixon plots showed all of the compounds to be competitive inhibitors of renin.All but D-α-hydroxyisovaleryl-Leu-Val-Phe-OCH3 were found to be more active than the known tetrapeptideinhibitor Leu-Leu-Val-Phe-OCH3 (1).The two most active compounds of the series were L-α-hydroxyisocaproyl-Leu-Val-Phe-OCH3 (Ki = 0.23 mM) and L-α-hydroxyisovaleryl-Leu-Val-Phe-OCH3 (Ki = 0.3 mM).