73631-21-7Relevant articles and documents
Synthesis and Diuretic Profile of 3-(3-Amino-1,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine, an Amiloride-Type Diuretic
Watthey, Jeffrey W. H.,Desai, Mahesh,Rutledge, Richard,Dotson, Ronald
, p. 690 - 692 (2007/10/02)
The synthesis of an analogue of amiloride in which the acylguanidine moiety has been replaced by a 1,2,4-oxadiazol-3-amine unit is described.This substance (3, CGS 4270) exhibited a diuretic profile similar to that of amiloride when evaluated in the rat a