7364-27-4

Basic information

• Product Name: 5-BROMO-3-HYDROXY (1H)INDAZOLE
• Synonyms: 5-BROMO-3-HYDROXY (1H)INDAZOLE;5-BROMO-1,2-DIHYDRO-INDAZOL-3-ONE;5-BROMO-3-HYDROXYINDAZOLE;5-Bromo-1H-indazol-3-ol;3H-Indazol-3-one, 5-broMo-1,2-dihydro-;5-broMo-1,2-dihydro-3H-Indazol-3-one
• CAS NO: 7364-27-4
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 213.03
• Mol File: 7364-27-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 209.098 °C
• Flash Point: 209.098°C
• Appearance: /
• Density: 1.942 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.784
• Storage Temp.: 2-8°C
• PKA: 11.02±0.20(Predicted)
• CAS DataBase Reference: 5-BROMO-3-HYDROXY (1H)INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-HYDROXY (1H)INDAZOLE(7364-27-4)
• EPA Substance Registry System: 5-BROMO-3-HYDROXY (1H)INDAZOLE(7364-27-4)

Safety Data

• Hazardous Substances Data: 7364-27-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-3-hydroxy(1H)indazole is a chemical compound with the molecular formula C7H5BrN2O. It is an indazole derivative and belongs to the class of organic compounds known as indazoles. 5-Bromo-3-hydroxy (1H)indazole has a bromine atom at the 5-position and a hydroxyl group at the 3-position, making it a bromo-hydroxy substituted indazole. It is used as an intermediate in the synthesis of pharmaceuticals and organic compounds, and it has potential applications in medicinal chemistry and drug development. 5-Bromo-3-hydroxy(1H)indazole is known for its wide range of biological activities, including anticonvulsant and antifungal properties, which make it a valuable compound in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C7H5BrN2O/c8-4-1-2-6-5(3-4)7(11)10-9-6/h1-3H,(H2,9,10,11)

Upstream product

• 7364-25-2 3-indazolinone 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 177192-82-4 C₇H₇BrN₂O₂ 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 
• 445-29-4 o-fluoro-benzoic acid 
• 57381-59-6 methyl 2-fluoro-5-bromobenzoate 
• 32253-75-1 5-bromo-2-<(carboxymethyl)amino>-benzoic acid 
• 141122-59-0 3-(4-Bromo-2-carboxyphenyl)sydnone 

Downstream Products

• 1096711-81-7 C₂₁H₁₅BrClN₃O₄S 
• 1096711-82-8 C₂₁H₁₄Br₂ClN₃O₄S 
• 1096711-88-4 C₁₉H₁₃BrN₄O₂S 
• 1096711-95-3 C₂₃H₁₆BrN₃O₄S 
• 1096711-83-9 C₁₈H₁₆BrN₃O₅S 
• 1096711-89-5 C₁₉H₁₃BrN₄O₂S 

Relevant articles and documents

Discovery of isatin and 1H-indazol-3-ol derivatives as D-amino acid oxidase (DAAO) inhibitors

D-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain D-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. A pharmacophore and structure-activity relationship analysis of isatins and reported DAAO inhibitors led us to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. The series was further characterized by pKa and isothermal titration calorimetry measurements. Representative compounds exhibited beneficial properties in in vitro metabolic stability and PAMPA assays. 6-fluoro-1H-indazol-3-ol (37) significantly increased plasma D-serine level in an in vivo study on mice. These results show that the 1H-indazol-3-ol series represents a novel class of DAAO inhibitors with the potential to develop drug candidates.

ISOINDOLINONE COMPOUNDS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS

The present invention relates to isoindolinone compounds. The isoindolinone compounds are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The invention furthermore relates to the u

NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE

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