7364-33-2

Basic information

• Product Name: 3-HYDROXY-6-NITRO (1H)INDAZOLE
• Synonyms: 3-HYDROXY-6-NITRO (1H)INDAZOLE;1,2-dihydro-6-nitro-3H-indazol-3-one;3-HYDROXY-6-NITROINDAZOLE;6-Nitro-3-indazolinone;6-nitro-1H-indazol-3(2H)-one;6-Nitro-1,2-dihydro-indazol-3-one;3H-Indazol-3-one, 1,2-dihydro-6-nitro-
• CAS NO: 7364-33-2
• Molecular Formula: C₇H₅N₃O₃
• Molecular Weight: 179.13
• EINECS: 230-905-8
• Mol File: 7364-33-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 243℃
• Boiling Point: 275℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.506
• Vapor Pressure: 0.00536mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-HYDROXY-6-NITRO (1H)INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-6-NITRO (1H)INDAZOLE(7364-33-2)
• EPA Substance Registry System: 3-HYDROXY-6-NITRO (1H)INDAZOLE(7364-33-2)

Safety Data

• Hazardous Substances Data: 7364-33-2(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-6-nitro (1H) indazole is a chemical compound with the molecular formula C7H5N3O3. It is a nitro-substituted indazole derivative that is commonly used in organic synthesis and medicinal chemistry. This chemical is known for its potential as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has been studied for its anti-tumor and anti-inflammatory properties. Additionally, 3-hydroxy-6-nitro (1H) indazole has also been investigated for its potential use in the treatment of neurological disorders and as a cytotoxic agent.

InChI:InChI=1/C7H5N3O3/c11-7-5-2-1-4(10(12)13)3-6(5)8-9-7/h1-3H,(H2,8,9,11)

Upstream product

• 619-17-0 4-Nitroanthranilic acid 
• 392-09-6 2-fluoro-4-nitro-benzoic acid methyl ester 
• 618445-83-3 3,3-dimethyl-1-piperidin-4-ylmethyl-2,3-dihydro-1H-indol-6-ylamine 
• 453562-51-1 {2-[4-(tert-butyl)-2-amino-phenoxy]-ethyl}-dimethylamine 
• 453562-53-3 1-[2-(tert-butyl)-5-aminophenyl]-4-methylpiperazine 

Downstream Products

• 107753-57-1 methyl 4-[3-hydroxy-6-nitroindazol-1-ylmethyl]-3-methoxybenzoate 
• 21413-23-0 3-chloro-6-amino-1H-indazole 
• 50593-68-5 3-chloro-6-nitro-1H-indazole 
• 59673-74-4 6-amino-1,2-dihydro-3H-indazole-3-one 

Relevant articles and documents

Discovery of isatin and 1H-indazol-3-ol derivatives as D-amino acid oxidase (DAAO) inhibitors

D-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain D-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. A pharmacophore and structure-activity relationship analysis of isatins and reported DAAO inhibitors led us to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. The series was further characterized by pKa and isothermal titration calorimetry measurements. Representative compounds exhibited beneficial properties in in vitro metabolic stability and PAMPA assays. 6-fluoro-1H-indazol-3-ol (37) significantly increased plasma D-serine level in an in vivo study on mice. These results show that the 1H-indazol-3-ol series represents a novel class of DAAO inhibitors with the potential to develop drug candidates.

SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Indazole derivatives as inhibitors of hormone sensitive lipase

The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.