73717-89-2

Basic information

• Product Name: 5-(4-Chloro-benzyl)-2-[2-(5-dimethylaminomethyl-furan-2-ylmethylsulfanyl)-ethylamino]-1H-pyrimidin-4-one
• CAS NO: 73717-89-2
• Molecular Weight: 432.974
• Mol File: 73717-89-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-Chloro-benzyl)-2-[2-(5-dimethylaminomethyl-furan-2-ylmethylsulfanyl)-ethylamino]-1H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chloro-benzyl)-2-[2-(5-dimethylaminomethyl-furan-2-ylmethylsulfanyl)-ethylamino]-1H-pyrimidin-4-one(73717-89-2)
• EPA Substance Registry System: 5-(4-Chloro-benzyl)-2-[2-(5-dimethylaminomethyl-furan-2-ylmethylsulfanyl)-ethylamino]-1H-pyrimidin-4-one(73717-89-2)

Safety Data

• Hazardous Substances Data: 73717-89-2(Hazardous Substances Data)

Upstream product

• 66356-53-4 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine 
• 63204-28-4 5-(4-chlorobenzyl)-2-methylthiopyrimid-4-one 

Relevant articles and documents

Isocytosine H2-receptor histamine antagonists. III. The synthesis and biological activity of lupitidine (SK and F 93479) and related compounds

A series of 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-4-pyrimidones is described containing a variety of substituents in the 5-position of the pyrimidone (isocytosine) ring. Good H2-receptor histamine antagonist activity is retained over a range of basic and neutral, polar and non-polar substituents and the majority of compounds are selective for the H2-receptor. Modifications have also been made to the furan ring and N,N-dimethylaminomethyl substituent and structure-activity observations are discussed. Compound (16f) 2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-5-(6-methyl-3- pyridylmethyl)-4-pyrimidone (SK and F 93479, lupitidine), a compound which shows an extended duration of anti-secretory activity in animal models, was selected for clinical investigation.