73734-45-9

Basic information

• Product Name: 1H-Benzimidazol-2-amine, N-[1-(2-phenylethyl)-4-piperidinyl]-
• CAS NO: 73734-45-9
• Molecular Formula: C20H24N4
• Molecular Weight: 320.437
• Mol File: 73734-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazol-2-amine, N-[1-(2-phenylethyl)-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine, N-[1-(2-phenylethyl)-4-piperidinyl]-(73734-45-9)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine, N-[1-(2-phenylethyl)-4-piperidinyl]-(73734-45-9)

Safety Data

• Hazardous Substances Data: 73734-45-9(Hazardous Substances Data)

Upstream product

• 24089-69-8 8-Phenethyl-1,4-dioxa-8-aza-spiro[4.5]decane; hydrochloride 
• 51448-56-7 4-amino-1-(2-phenylethyl)-piperidine 
• 39742-60-4 1-(2-phenylethyl)-4-piperidinone 
• 103-63-9 1-phenyl-2-bromoethane 
• 75970-47-7 (1H-benzimidazol-2-yl)-(4-piperidinyl)amine dihydrobromide 

Downstream Products

• 75971-18-5 1-[1-(4-fluorophenyl)ethyl]-N-[1-(2-phenylethyl)-4-piperidinyl]-1H-benzimidazol-2-amine 
• 98244-96-3 [1-(2-Chloro-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine 
• 98245-00-2 (1-Phenethyl-piperidin-4-yl)-[1-(1-phenyl-ethyl)-1H-benzoimidazol-2-yl]-amine 
• 98244-98-5 [1-(4-Bromo-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-97-4 [1-(4-Chloro-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine 
• 98088-84-7 1-(4-fluorobenzyl)-N-(1-phenethylpiperidin-4-yl)-1H-benzo[d]imidazol-2-amine 
• 98244-99-6 [1-(4-Methyl-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-94-1 (1-Heptyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-95-2 (1-Cyclopentyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-93-0 (1-Hexyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-92-9 (1-Pentyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-91-8 (1-Butyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-90-7 (1-Isopropyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 
• 98244-89-4 (1-Phenethyl-piperidin-4-yl)-(1-propyl-1H-benzoimidazol-2-yl)-amine 

Relevant articles and documents

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

The synthesis of a series N-(4-piperidinyl)-1H-benzimidazol-2-amines and the preliminary evaluation of their in vitro and in vivo antihistaminic activity are described. Cyclodesulfurization of (2-aminophenyl) thioureas with mercury(II) oxide resulted in 2-aminobenzimidazole intermediates, which were monoalkylated on the endo-nitrogen atom. After deprotection of the piperideine nitrogen atom with 48% aqueous hydrobromic acid solution, the title compounds were obtained by three different methods, viz. alkylation, reductive amination, or oxirane ring-opening reactions. The in vivo antihistaminic activity was evaluated by the compound 48/80 induced lethality test in rats and histamine-induced lethality test in guinea pigs after oral and/or subcutaneous administration. The duration of action, for a selected number of compounds, was studied in the guinea pig. The phenylethyl derivatives showed the most potent antihistamine properties after oral administration in both animal species.