73742-63-9

Basic information

• Product Name: 4-Mercapto-3-pyridinesulfonamide
• Synonyms: 3-Pyridinesulfonamide,4-mercapto-(9CI);4-Mercapto-3-pyridinesulfonamide;3-PyridinesulfonaMide, 4-Mercapto-;Mercapto-4 Pyridin-sulfonamid-3
• CAS NO: 73742-63-9
• Molecular Formula: C5H6N2O2S2
• Molecular Weight: 190.24
• Product Categories: SULFONAMIDE
• Mol File: 73742-63-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 345.6 °C at 760 mmHg
• Flash Point: 162.8 °C
• Appearance: /
• Density: 1.63 g/cm³
• Vapor Pressure: 6.09E-05mmHg at 25°C
• Refractive Index: 1.72
• Storage Temp.: 2-8°C
• PKA: 1.13±0.48(Predicted)
• CAS DataBase Reference: 4-Mercapto-3-pyridinesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Mercapto-3-pyridinesulfonamide(73742-63-9)
• EPA Substance Registry System: 4-Mercapto-3-pyridinesulfonamide(73742-63-9)

Safety Data

• Hazardous Substances Data: 73742-63-9(Hazardous Substances Data)

Usage

General Description

4-Mercapto-3-pyridinesulfonamide is a chemical compound with the molecular formula C6H7NOS2. It is a sulfonamide derivative containing a pyridine ring and a mercapto group. 4-Mercapto-3-pyridinesulfonamide is known for its potential applications in the pharmaceutical industry, where it is used as a building block for the synthesis of various pharmaceutical drugs. It also exhibits antibacterial and antimicrobial properties, making it valuable for medicinal purposes. Additionally, 4-Mercapto-3-pyridinesulfonamide has been studied for its potential as an antioxidant and antitumor agent. Its diverse range of properties and potential applications make it a compound of interest in the field of medicinal chemistry and drug development.

InChI:InChI=1/C5H6N2O2S2/c6-11(8,9)5-3-7-2-1-4(5)10/h1-3H,(H,7,10)(H2,6,8,9)

Upstream product

• 1078159-94-0 potassium 1,1-dioxopyrido[4,3-e]-1,4,2-dithiazine-3-thiolate 
• 1229666-32-3 2-(3-sulfamoyl-4-pyridyl)thiouronium chloride 

Downstream Products

• 353278-70-3 4-(benzylthio)pyridine-3-sulfonamide 

Relevant articles and documents

Carbonic anhydrase inhibitors: Synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides

A series of novel 4-substituted-3-pyridinesulfonamides (2-27 and 31-33) have been synthesized and investigated as inhibitors of five isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), that is, the cytosolic, ubiquitous isozymes CA I and II, and transmembrane isozymes CA IX, XII (cancer-associated) and XIV. Against the human isozymes hCA I, the new compounds showed inhibition constants in the range of 0.078-11.7 μM, against hCA II in the range of 9.9-140 nM, against hCA IX in the range of 4.6-313 nM, against hCA XII in the range of 3.4-21.6 nM, and against hCA XIV in the range of 50.9-160 nM, respectively. Compounds 4, 6, 7, 9, 11-14, 19, 20, 22-24, 26, 27, 31 and 32 showed excellent hCA IX inhibitory efficacy, with inhibition constants of 4.6-12.0 nM, being much more effective as compared to the clinically used sulfonamides AAZ, MZA, EZA, DCP and IND. 4-[N′-(6-Chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide (31) is the prominent of the compounds due to its remarkable inhibitory activity toward hCA I (KIs = 0.078 μM), hCA IX (KIs = 7.2 nM) and hCA XII (KIs = 3.4 nM).