737758-35-9Relevant articles and documents
P-cymenesulphonyl chloride: A bio-based activating group and protecting group for greener organic synthesis
Farmer, Thomas J.,Clark, James H.,Gothe, Maite L.,Macquarrie, Duncan J.,Sherwood, James
, p. 1914 - 1919 (2015/09/22)
A bio-derived protecting/activating group has been synthesized by introducing a sulphonyl chloride group to the aromatic ring of p-cymene derived from citrus peel waste. The resulting p-cymenesulphonyl chloride was evaluated as an activating group by reacting with 1-octanol, 2-octanol, phenol and piperidine, and further reactions of the activated alcohols. The comparison to tosyl chloride demonstrates that the bio-based alternative can be effectively utilized as a direct replacement for the current fossil derived equivalent.