73818-26-5Relevant articles and documents
Nickel(II) 2,6-diacetylpyridine bis(isonicotinoylhydrazonate) and bis(benzoylydrazonate) complexes: Structure and antimycobacterial evaluation. Part XI
Bottari,Maccari,Monforte,Ottana,Vigorita,Bruno,Nicolo,Rotondo,Rotondo
, p. 2203 - 2211 (2001)
The reaction of 2,6-diacetylpyridine (dap) and isonicotinoyl- or benzoylhydrazide leads to bishydrazones H2dapin (1a) and H2dapb (1b), respectively. The condensation can either take place as a bimolecular kinetic process between the two reactants or as a monomolecular metal-templated synthesis in the presence of nickel(II) ions. In the latter case the reaction products are charged 2,6-diacetylpyridine bis(hydrazone) nickel(II) complexes, which can be easily deprotonated to neutral hydrazonates. Diffractometric analysis of one of these [Ni(dapb)]2 (8b) has shown a binuclear structure with two octahedral nickel(II) ions bridged by two helicoidal dap (bishydrazonates) in a spheroidal structure of C2V symmetry. The synthesized complexes 8 are promising as antimycobacterial agents against M. tuberculosis H37Rv. In particular, 8b displays significant activity (MIC = 0.025 μg/mL) 10-fold higher than rifampin and equal to isoniazid, while its ligand is ineffective. Compound 8b is also capable of reducing HIV-induced cytopathogenic effect in human T4lymphocytes.
The first pentagonal-bipyramidal vanadium(iii) complexes with a Schiff-base N3O2pentadentate ligand: Synthesis, structure and magnetic properties
Bazhenova, Tamara A.,Klingeler, Rüdiger,Koo, Changhyun,Manakin, Yuriy V.,Maximova, Olga V.,Mironov, Vladimir S.,Simonov, Sergey V.,Spillecke, Lena,Vasiliev, Alexander N.,Yagubskii, Eduard B.,Zorina, Leokadiya V.
, p. 15287 - 15298 (2020)
A series of three mononuclear pentagonal-bipyramidal V(iii) complexes with the equatorial pentadentate N3O2 ligand (2,6-diacethylpyridinebis(benzoylhydrazone), H2DAPBH) in the different charge states (H2DAPBH0, HDAPBH1-, DAPBH2-) and various apical ligands (Cl-, CH3OH, SCN-) were synthesized and characterized structurally and magnetically: [V(H2DAPBH)Cl2]Cl·C2H5OH (1), [V(HDAPBH)(NCS)2]·0.5CH3CN·0.5CH3OH (2) and [V(DAPBH)(CH3OH)2]Cl·CH3OH (3). All three complexes reveal paramagnetic behavior, resulting from isolated S = 1 spins with positive zero-field splitting energy expected for the high-spin ground state of the V3+ (3d2) ion in a PBP coordination. Detailed high-field EPR measurements for compound 3 show that its magnetic properties are best described by using the spin Hamiltonian with the positive ZFS energy (D = +4.1 cm-1) and pronounced dimer-like antiferromagnetic spin coupling (J = -1.1 cm-1). Theoretical analysis based on superexchange calculations reveals that the long-range spin coupling between distant V3+ ions (8.65 ?) is mediated through π-stacking contacts between the planar DAPBH2- ligands of two neighboring [V(DAPBH)(CH3OH)2]+ complexes.
Synthesis, anticancer activity and mechanism of iron chelator derived from 2,6-diacetylpyridine bis(acylhydrazones)
Yao, Qian,Qi, Jinxu,Zheng, Yunyun,Qian, Kun,Wei, Lai,Maimaitiyiming, Mukedasi,Cheng, Zhen,Wang, Yihong
, p. 1 - 8 (2019/01/16)
We synthesized five iron chelator derived from 2,6-diacetylpyridine bis(acylhydrazones) and proved their iron complexes structure by X–ray single crystal diffraction. These ligands have a significant anticancer proliferative activity and low cytotoxicity
