7385-87-7

Basic information

• Product Name: 8-BROMO-NAPHTHALEN-2-OL
• Synonyms: 8-BROMO-NAPHTHALEN-2-OL;2-Naphthalenol, 8-broMo-;8-bromo-2-Naphthalenol
• CAS NO: 7385-87-7
• Molecular Formula: C₁₀H₇BrO
• Molecular Weight: 223.07
• Mol File: 7385-87-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 113-114 °C
• Boiling Point: 353.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.614±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.12±0.40(Predicted)
• CAS DataBase Reference: 8-BROMO-NAPHTHALEN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 8-BROMO-NAPHTHALEN-2-OL(7385-87-7)
• EPA Substance Registry System: 8-BROMO-NAPHTHALEN-2-OL(7385-87-7)

Safety Data

• Hazardous Substances Data: 7385-87-7(Hazardous Substances Data)

Usage

General Description

8-Bromo-naphthalen-2-ol is a chemical compound with the molecular formula C10H7BrO. It is an aromatic compound with a bromine atom attached to a naphthalene ring and a hydroxyl group at the 2 position. It is commonly used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. The compound is also known for its potential use in the preparation of fluorescent polymers and as a reagent in various chemical reactions. Additionally, 8-bromo-naphthalen-2-ol is known to have antimicrobial and antifungal properties, making it a potential candidate for use in the development of new drugs and antimicrobial agents.

Upstream product

• 93261-69-9 8-bromo-2-benzoyloxynaphthalene 
• 118-46-7 8-amino-2-naphthol 
• 93259-50-8 p-Toluolsulfonsaeure-<8-brom-naphthyl-(2)-ester> 
• 7385-85-5 naphthalen-2-yl tosylate 
• 135-19-3 β-naphthol 
• 90-11-9 1-Bromonaphthalene 
• 93-44-7 2-naphthyl benzoate 
• 117294-21-0 8-bromo-2-tetralone 

Downstream Products

• 144876-32-4 7-hydroxy-1-naphthaldehyde 

Relevant articles and documents

Formation of Phenalenone Skeleton by an Unusual Rearrangement Reaction

The frame rearrangement reaction of dinaphthyl ketones, possessing hydroxy groups at appropriate positions, into phenalenone derivatives under acidic conditions was discovered serendipitously. Although this rearrangement had limited scope, its mechanism was unusual, involving the division of naphthalene rings into one phenalenone ring and one benzene ring. The reaction mechanism was elucidated by direct determination of intermediate structures using 1H NMR measurements. The generated phenalenones are expected to be key intermediates toward natural products and functional materials.

Rational molecular designs for drastic acceleration of the color-fading speed of photochromic naphthopyrans

We report rational molecular designs for acceleration of the color-fading speed of photochromic 3H-naphthopyrans. By using steric and electrostatic repulsions induced by substituents at the 2- and 10-positions of 3H-naphthopyrans, the color-fading speed accelerates from tens of minutes to microsecond time scales. The long-lived residual color, which is an important problem to be solved for industrial applications, can also be suppressed by these strategies.

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.