73863-50-0

Basic information

• Product Name: 2-Chloro-3-(2-chloroethyl)-7-methylquinoline
• Synonyms: 2-Chloro-3-(2-chloroethyl)-7-methyl-quinoline
• CAS NO: 73863-50-0
• Molecular Formula: C12H11 Cl2 N
• Molecular Weight: 240.13
• Mol File: 73863-50-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 363.5°C at 760 mmHg
• Flash Point: 205°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 3.76E-05mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 2-Chloro-3-(2-chloroethyl)-7-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-(2-chloroethyl)-7-methylquinoline(73863-50-0)
• EPA Substance Registry System: 2-Chloro-3-(2-chloroethyl)-7-methylquinoline(73863-50-0)

Safety Data

• Hazardous Substances Data: 73863-50-0(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-(2-chloroethyl)-7-methylquinoline is a compound with the chemical formula C13H11Cl2N. It is a derivative of quinoline, a heterocyclic aromatic compound. The molecule contains two chlorine atoms, one ethyl group, and one methyl group attached to the quinoline ring. 2-Chloro-3-(2-chloroethyl)-7-methylquinoline may have applications in pharmaceutical and chemical research due to its potential biological activity. Its synthesis and properties make it a valuable compound for further study in the field of organic chemistry and drug development.

InChI:InChI=1/C12H11Cl2N/c1-8-2-3-9-7-10(4-5-13)12(14)15-11(9)6-8/h2-3,6-7H,4-5H2,1H3

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 73863-44-2 N-(4-chlorobutyryl)-m-toluidine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 73863-55-5 3-(2-chloroethyl)-7-methyl-2-quinolone 
• 73863-57-7 2,3-dihydro-7-methylfuro[2,3-b]quinoline 

Relevant articles and documents

A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 8. Conversion of Anilides into 3-Substituted Quinolines and into Quinoxalines

Anilides (4) (ArNHCOCH2R) are readily converted into 2-chloro-3-R-quinolines (5) under Vilsmeier conditions and the 3-chloro-group may be removed with zinc and acetic acid yielding 3-substituted quinolines (7).When N-nitrosodialkylamines are used in place of dimethylformamide as the Vilsmeier agent, the anilides are converted into 2-chloroquinoxalines in low yields.Several by-products are formed and the mechanisms have been explored.Thus, the formation of ethyl N-arylcarbamate from the corresponding propionanilide is shown to involve an C->O alkyl migration related to a Wolff rearrangement, while N-arylformimidoyl dichloride (18), nitriles, and isocyanides are derived from C-C cleavage of the substituted side-chain.Variation of the acid chloride component of the Vilsmeier reagent or of the solvent was generally unproductive though use of phosphoryl bromide instead of the chloride caused conversion of anilides into bromoquinolines in low yields.