73872-14-7

Basic information

• Product Name: (2S,4'S,5'S)-(+)-2-Amino-N-(2',2'-dimethyl-4'-phenyl-1',3'-dioxan-5'-yl)-2-phenylacetonitril
• Synonyms: (2S,4'S,5'S)-(+)-2-Amino-N-(2',2'-dimethyl-4'-phenyl-1',3'-dioxan-5'-yl)-2-phenylacetonitril
• CAS NO: 73872-14-7
• Molecular Weight: 322.407
• Mol File: 73872-14-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,4'S,5'S)-(+)-2-Amino-N-(2',2'-dimethyl-4'-phenyl-1',3'-dioxan-5'-yl)-2-phenylacetonitril(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4'S,5'S)-(+)-2-Amino-N-(2',2'-dimethyl-4'-phenyl-1',3'-dioxan-5'-yl)-2-phenylacetonitril(73872-14-7)
• EPA Substance Registry System: (2S,4'S,5'S)-(+)-2-Amino-N-(2',2'-dimethyl-4'-phenyl-1',3'-dioxan-5'-yl)-2-phenylacetonitril(73872-14-7)

Safety Data

• Hazardous Substances Data: 73872-14-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 35019-66-0 (4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-amine 
• 773837-37-9 sodium cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 29738-09-8 (R)-2-amino-2-phenylpropanoic acid 
• 33875-38-6 (R)-2‐amino‐2‐phenylbutyric acid 
• 6278-95-1 (R)-(+)-α-benzyl-α-phenylglycine 
• 2935-35-5 (S)-2-phenylglycine 

Relevant articles and documents

Enantioselective Synthesis of α-Quaternary Amino Acids by Alkylation of Deprotonated α-Aminonitriles

A series of α-quaternary arylglycines were prepared in high optical purity (up to 98% ee) by α-alkylation of deprotonated α-aminonitriles derived by the Strecker reaction from (4S,5S)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane. The procedure includes only chromatographic purification of the final products and is devoid of chromatography or crystallization operations on intermediates to raise the optical purity.

Nonproteinogenic Amino Acids, I.- A Simple Asymmetric Synthesis of (S)-(+)-2-Phenyl-and (S)-(+)-2-Anisylglycine

A three-step synthesis of optically pure (S)-(+)-2-phenyl-and (S)-(+)-2-anisylglycine (6a and b) is described.Although the yields are only about 50percent, this synthesis nevertheless offers advantages over those involving a racemate cleavage.