73895-87-1Relevant articles and documents
Process for the preparation of an anticonvulsant compound
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, (2014/05/24)
The invention provides a novel method for the preparation of intermediates useful in a process designed to obtain known 1,2,4-triaminobenzene compounds, and in particular a specific compound thereof having known anticonvulsant activity. Unlike known methods, the novel method does not require advance protection of the amino groups present on the substrate.
PROCESS FOR THE PREPARATION OF RETIGABINE OF THE FORMULA I AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
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, (2013/03/26)
The invention relates to process for the preparation of 2-amino-4-(4- fluorobenzylamino)-l-ethoxycarbonylaminobenzene generically known as Retigabine of the formula (I) and its pharmaceutically acceptable salts e.g. Formula IA, particularly to the modification over the prior art processes-I and II disclosed therein in US5384330. The modifications are depicted in the scheme I and scheme II respectively. Disclosed herein are also the novel processes for the preparation of intermediates of formulae M, N and O of the process-I and of formulae R, S, T of process-II, those are used for preparation of Retigabine of the formula I and its pharmaceutically acceptable salts thereof.
Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes for their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
Pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula I: STR1 where the symbols R1' R2' R3' R4' R5' Ar and Alk have the following meanings: where the symbols R1, R2, R3, R4, R5, Ar and Alk have the following meanings: R1 : hydrogen, C1 -C6 -alkyl, C2 -C6 -alkanoyl or the radical Ar; R2 : hydrogen or C1 -C6 -alkyl; R3 : C1 -C6 -alkoxy, NH2, C1 -C6 -alkylamino, C1 -C6 -dialkylamino, amino substituted by the radical Ar, C1 -C6 -alkyl, C2 -C6 -alkenyl, C2 -C6 -alkynyl, the radical Ar or the radical ArO--; R4 : hydrogen, C1 -C6 -alkyl or the radical Ar; R5 : hydrogen or C1 -C6 -alkyl or the radical Ar; Alk: a straight or branched alkylene group containing 1-9 carbon atoms, which can also be substituted by the radical Ar.
