73908-23-3

Basic information

• Product Name: (1S)-2-bromo-1-phenyl-ethanol
• Synonyms: (1S)-2-bromo-1-phenyl-ethanol;(R)-α-(broMoMethyl)benzyl alcohol;(1R)-2-bromo-1-phenylethanol
• CAS NO: 73908-23-3
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.060460
• Mol File: 73908-23-3.mol
• Article Data: 141

Chemical Properties

• Boiling Point: 261.634 °C at 760 mmHg
• Flash Point: 135.55 °C
• Appearance: /
• Density: 1.504 g/cm³
• CAS DataBase Reference: (1S)-2-bromo-1-phenyl-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-2-bromo-1-phenyl-ethanol(73908-23-3)
• EPA Substance Registry System: (1S)-2-bromo-1-phenyl-ethanol(73908-23-3)

Safety Data

• Hazardous Substances Data: 73908-23-3(Hazardous Substances Data)

Upstream product

• 10409-54-8 2-bromo-2-methyl-1-phenyl-propan-1-one 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 103-63-9 1-phenyl-2-bromoethane 
• 20780-53-4 (R)-Styrene oxide 
• 2425-28-7 2-Bromo-1-phenylethanol 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 
• 98-86-2 acetophenone 
• 1483-82-5 phenylethynyl chloride 
• 100-42-5 styrene 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 5205-07-2 3-methyl-3-buten-1-yl acetate 
• 108-05-4 vinyl acetate 
• 36567-72-3 (S)-3-hydroxy-3-phenylpropanoic acid 

Downstream Products

• 20780-53-4 (R)-Styrene oxide 
• 1445-91-6 (S)-1-phenylethanol 
• 1517-69-7 (R)-1-phenylethanol 
• 126923-26-0 (R)-2-azido-2-phenylethan-1-ol 
• 67341-01-9 (R)-N-(tert-butoxycarbonyl)phenylglycinol 
• 56613-80-0 D-2-phenylglycinol 
• 134625-72-2 (R)-2-azido-1-phenylethanol 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 247041-12-9 (S)-(+)-2-phenoxy-1-phenyl-ethanol 
• 124817-06-7 (S)-2-azido-1-phenylethanol 
• 95977-53-0 (S)-2-(N,N-dimethylamino)-2-phenylethanol 
• 34469-09-5 (R)-2-dimethylamino-1-phenyl-ethanol 
• 20780-54-5 (S)-styrene oxide 
• 5837-69-4 (RS)-1-bromo-2-acetoxy-2-(phenyl)ethane 

Relevant articles and documents

Unmasking the Hidden Carbonyl Group Using Gold(I) Catalysts and Alcohol Dehydrogenases: Design of a Thermodynamically-Driven Cascade toward Optically Active Halohydrins

A concurrent cascade combining the use of a gold(I) N-heterocyclic carbene (NHC) and an alcohol dehydrogenase (ADH) is disclosed for the synthesis of highly valuable enantiopure halohydrins in an aqueous medium and under mild reaction conditions. The meth

Chiral salen - Ni (II) based spherical porous silica as platform for asymmetric transfer hydrogenation reaction and synthesis of potent drug intermediate montekulast

Heterogeneous catalyst has an edge over homogeneous systems in terms of recyclability, activity, stability and recovery. Silica has evolved as a good support material in heterogeneous systems due to its stability and ability to get modified as per the end application. Herein, we report a novel chiral Ni-Schiff base derived catalyst and its immobilization into mesoporous silica which was synthesized by post-grafting process. The chiral catalyst demonstrated remarkably high catalytic activity, enantioselectivity (up to 99 % enantiomers excess) for heterogeneous asymmetric transfer hydrogenation of various ketones. The developed catalyst was characterized by Ultraviolet-visible spectroscopy (UV–vis), Fourier-Transform Infrared spectroscopy (FT-IR), X-ray Powder Diffraction (XRD), Brunauer-Emmett-Teller (BET isotherm), Scanning Electron Microscopy – Energy Dispersive X-ray Spectroscopy (SEM-EDX), High Resolution – Transmission Electron Microscopy (HR-TEM), Vibrating Sample Magnetometer (VSM), X-ray Photoelectron Spectroscopy (XPS) and elemental analysis. The catalyst could be recovered and reused for multiple consecutive runs without losing the enantioselectivity. The chiral catalyst was used in asymmetric transfer hydrogenation reaction for synthesizing enantiomerically pure drug intermediate Montekulast.

Asymmetric Catalytic Meerwein-Ponndorf-Verley Reduction of Ketones with Aluminum(III)-VANOL Catalysts

We report herein an efficient aluminum-catalyzed asymmetric MPV reduction of ketones with broad substrate scope and excellent yields and enantiomeric inductions. A variety of aromatic (both electron-poor and electron-rich) and aliphatic ketones were converted to chiral alcohols in good yields with high enantioselectivities (26 examples, 70-98percent yield and 82-99percent ee). This method operates under mild conditions (-10 °C) and low catalyst loading (1-5 mol percent). Furthermore, this process is catalyzed by the earth-abundant main-group element aluminum and employs 2-propanol as the hydride source.