7391-40-4Relevant articles and documents
Synthesis and Docking Study of Novel Pyranocoumarin Derivatives
Karteek, S. Durga,Reddy, A. Gopi,Tej, M. Bhuvan,Rao, M. V. Basaveswara
, p. 272 - 282 (2021/04/02)
Abstract: A new series of fused tricyclic coumarin derivatives were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by molecular docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compounds.
Preparation method for N,N-dimethylcyanoacetamide
-
Paragraph 0014; 0015; 0016; 0017, (2018/04/26)
The invention discloses a preparation method for N,N-dimethylcyanoacetamide (DMCA). The method is characterized by comprising the following steps: (1) adding a dimethylamine aqueous solution into methyl cyanoacetate dropwise under the temperature of -15 to 0 DEG C, and performing a reaction under stirring for 1-2h; (2) enabling the temperature to return to a room temperature, continuing a reactionunder stirring for 2-3h, then adding toluene, and performing heating refluxing; and raising the temperature to 35 DEG C, performing a reaction for 20-30min, raising the temperature again to 42 DEG C,performing a reaction for 10min, and performing natural cooling to the room temperature; (3) performing a microwave reaction for 10min, then performing ultrasonic dispersion for 30-40min, performingnatural cooling to the room temperature; (4) allowing the obtained material to stand for 2-3h under the temperature of -5 DEG C for precipitating a solid; and (5) performing vacuum filtration, performing vacuum drying on the obtained solid. The method disclosed by the invention omits a reflux water separation process, greatly reduces the amount of waste water, makes the post-treatment process simplified and has the advantage of environmental protection; and the DMCA product obtained by the process has a white appearance, the purity reaches 99% or more, and the yield is 92.5%.
Optically active thiophenes via an organocatalytic one-pot methodology
Ransborg, Lars Krogager,Albrecht, Lukasz,Weise, Christian F.,Bak, Jesper R.,Jorgensen, Karl Anker
supporting information; experimental part, p. 724 - 727 (2012/04/11)
A general methodology for the synthesis of trisubstituted, optically active thiophenes by an organocatalytic one-pot reaction cascade is presented. The target products are synthesized in good yields (up to 92%) and with excellent enantioselectivities (up to 98% ee). Importantly, based on practical and easily available starting materials, the presented methodology can be conducted under mild reaction conditions. To further elucidate the generality, the synthesis of optically active thienoindoles, as well as selenophenes, is also demonstrated.
