73980-24-2Relevant articles and documents
CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Paragraph 00234; 001167; 001169, (2018/07/29)
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.
Studies on antihyperlipidemic agents. I. Synthesis and hypolipidemic activities of phenoxyphenyl alkanoic acid derivatives
Kawamatsu,Saraie,Imamiya,Nishikawa,Hamuro
, p. 454 - 458 (2007/10/02)
The alkanoic acids containing phenoxyphenyl moiety at ω-position were prepared and tested for hypolipidemic property. Some of the compounds showed hypoglycemic activity besides hypolipolipidemic one. Further study on the selected compound, 3-[4-(4-chlorophenoxy)benzoyl]propionic acid (8) revealed that it increased insulin sensitivity of adipose tissue of obese and diabetic mice (KKA(y)). The structure-activity relationship was discussed briefly.