7399-36-2 Usage
Also known as
3-bromophenylalanine
Derivative of
Phenylalanine
Use
Synthesis of biologically active compounds and pharmaceutical drugs
Ability
Alter structure and function of proteins
Applications
Treatment of neurological disorders, cancer, and other medical conditions
Research tool
Study of protein-protein interactions and drug design
Caution
Potential side effects and toxicity in use.
Check Digit Verification of cas no
The CAS Registry Mumber 7399-36-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,9 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 7399-36:
(6*7)+(5*3)+(4*9)+(3*9)+(2*3)+(1*6)=132
132 % 10 = 2
So 7399-36-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H10BrNO2/c1-9(11,8(12)13)6-3-2-4-7(10)5-6/h2-5H,11H2,1H3,(H,12,13)
7399-36-2Relevant articles and documents
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads
Rombouts, Frederik J. R.,Tresadern, Gary,Delgado, Oscar,Martínez-Lamenca, Carolina,Van Gool, Michiel,García-Molina, Aránzazu,Alonso De Diego, Sergio A.,Oehlrich, Daniel,Prokopcova, Hana,Alonso, José Manuel,Austin, Nigel,Borghys, Herman,Van Brandt, Sven,Surkyn, Michel,De Cleyn, Michel,Vos, Ann,Alexander, Richard,Macdonald, Gregor,Moechars, Dieder,Gijsen, Harrie,Trabanco, Andrés A.
, p. 8216 - 8235 (2015/11/09)
1,4-Oxazines are presented, which show good in vitro inhibition in enzymatic and cellular BACE1 assays. We describe lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active site. Our strategy permi
