74039-20-6

Basic information

• Product Name: 5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine
• Synonyms: 5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine
• CAS NO: 74039-20-6
• Molecular Formula: C5ClF5N2
• Molecular Weight: 0
• Mol File: 74039-20-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 244.6°C at 760 mmHg
• Flash Point: 101.8°C
• Appearance: /
• Density: 1.683g/cm³
• Vapor Pressure: 0.0469mmHg at 25°C
• Refractive Index: 1.412
• CAS DataBase Reference: 5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine(74039-20-6)
• EPA Substance Registry System: 5-Chloro-2,4-difluoro-6-trifluoromethylpyrimidine(74039-20-6)

Safety Data

• Hazardous Substances Data: 74039-20-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C5ClF5N2/c6-1-2(5(9,10)11)12-4(8)13-3(1)7

Upstream product

• 74039-25-1 6-trichloromethyl-2,4,5-trichloropyrimidine 
• 84372-18-9 5-Chloro-2,4-difluoro-6-trichloromethyl-pyrimidine 

Downstream Products

• 84737-35-9 2-fluoro-4-methoxy-5-chloro-6-trifluoromethyl pyrimidine 

Relevant articles and documents

FLUORINATED HETEROCYCLIC COMPOUNDS: SELECTIVE CHLORONE/FLUORINE EXCHANGE REACTIONS ON PYRIMIDINES

Selective chlorine/fluorine exchange reactions on tetrachloropyrimidine, 6-methyl-, 6-chloromethyl-, 6-dichloromethyl, and 6-trichloromethyl-2,4,5-trichloropyrimidine are described.Sodium fluoride, potassium fluoride, hydrogen fluoride, and antimony trifluoride were used as the fluorinating agents.It was found that NaF and KF fluorinate only in the heterocyclic nucleus, HF in the nucleus and in the chlorinated methyl group, and SbF3 only in the chlorinated methyl group.In the first stage of fluorination with NaF only chlorine bound in position 4 of the pyrimidine ring is exchanged.The HF reaction is an equilibrium reaction in which the substitution of the fluorine for the first chlorine atom occurs preferentially in position 2.The behaviour of partly fluorinated pyrimidines in nucleophilic exchange reactions is also discussed.