74087-90-4

Basic information

• Product Name: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
• Synonyms: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
• CAS NO: 74087-90-4
• Molecular Formula: C₁₆H₁₂N₂O₂S
• Molecular Weight: 296.34368
• Mol File: 74087-90-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone(74087-90-4)
• EPA Substance Registry System: 1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone(74087-90-4)

Safety Data

• Hazardous Substances Data: 74087-90-4(Hazardous Substances Data)

Upstream product

• 3004-42-0 5-phenyl-1,3,4-oxadiazole-2(3H)-thione 
• 70-11-1 α-bromoacetophenone 
• 613-94-5 benzoic acid hydrazide 
• 93-58-3 benzoic acid methyl ester 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 

Downstream Products

• 863301-82-0 2-bromo-1-phenyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-ethanone 
• 36256-78-7 2-(2-benzoylhydrazino)-4-methylthiazole 
• 81555-88-6 1-(5-Phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-propan-2-one 
• 81556-02-7 1,2-Diphenyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-ethanone 
• 81556-00-5 1-Phenyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-propan-1-one 
• 81556-01-6 2-(5-Phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-cyclohexanone 
• 81556-03-8 2-<(3-oxobutyl)thio>-5-phenyl-1,3,4-oxadiazole 
• 81556-04-9 3-phenyl-6-methyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 
• 81556-13-0 Benzoic acid N'-(4-phenyl-thiazol-2-yl)-hydrazide 
• 79074-65-0 3,6-diphenyl<1,2,4>triazolo<3,4-b><1,3,4>thiadiazine 

Relevant articles and documents

Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities

The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a-41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%.

Ring Transformation of 1,3,4-Oxadiazole to s-Triazole-Fused Heterocycles. New Synthetic Route for Thiazolo-s-triazole and 7H-s-Triazolothiadiazine

s-Triazole-fused heterocycles have been synthesized by an intramolecular transformation of some 1,3,4-oxadiazole ketones with ammonia or hydrazine.The α- ketone 2m gave thiazolo-s-triazole (4m), accompanied by a small amount of the hydrazide 9m on treatment with ammonium acetate in acetic acid.Similar treatment of ketones 2a and 2b afforded only the hydrazides 9a and 9b, respectively.Ketones 2a-n reacted with hydrazine hydrate in acetic acid to give 7H-s-triazolothiadiazines 5a-n.However, ketones 2o-q, with substituents α to the carbonyl group, could not be converted to the corresponding fused-ring systems.Mechanisms for these transformations are proposed.