74097-59-9Relevant articles and documents
Stereoselective synthesis of 3,5-dialkyl-3,5-dihydro-3,5-diphenyl-4H- pyrazol-4-ones
Moiseev, Andrey G.,Neckers, Douglas C.
, p. 2901 - 2905 (2007/10/03)
We report stereoselective five-step syntheses of cis-3-ethyl-3,5-dihydro-3, 5-diphenyl-5-methyl-4H-pyrazol-4-one (cis-1b) and trans-3,5-diethyl-3,5-dihydro- 3,5-diphenyl-4H-pyrazol-4-one (trans-1c). The key synthon was 1,3-diphenylpent-2-en-1-one (5b) synthesized in a new one-pot crossed aldol/dehydration reaction of acetophenone with propiophenone using titanium(IV) chloride/tributylamine, followed by treatment with methanesulfonyl chloride and triethylamine. Georg Thieme Verlag Stuttgart.