74106-81-3Relevant articles and documents
XANOMELINE DERIVATIVES AND METHODS FOR TREATING NEUROLOGICAL DISORDERS
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Paragraph 0235, (2021/05/21)
Provided herein are compounds comprising compounds of formula (I) and/or salts thereof; wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine, and the remainder are independently chosen from hydrogen and fluorine; and R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 are independently chosen from hydrogen and deuterium; with the proviso that when R1, R2, and R3 are fluorine, then at least one of R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine or at least one of R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23is deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.
Synthesis of 2, 2 - [...] acid ethyl ester method (by machine translation)
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Paragraph 0012; 0029-0031, (2018/04/01)
The invention relates to a method for synthesizing 2, 2 - [...] acid ethyl ester method, the glass in the reaction container, adding benzoin two thioether and 2, 6 - dimethyl - 1, 4 - dihydro - 3, 5 - pyridine dicarboxylic acid diethyl, replace the nitrogen glass after the air in the reaction container, adding butene and bromine two fluorine ethyl acetate, then adding solvent; the glass reaction container is placed on a blue light LED lamp or white light energy-saving lamp irradiation under 12 - 48 h, then remove the product in the solvent, adding petroleum ether product dissolved, adopts the 300 - 400 mesh silica gel as the stationary phase of column chromatography technology, wet in france type, in order to petroleum ether as eluent to elute, GC - MS detection product belt, and the collected [...] turns on lathe does, to get the. The method is simple in operation, solvent to the low quality requirement, can be corresponding to the multi-olefin, raw materials are easy, low cost, mild reaction conditions, and adopts a non-metal catalytic, preventing the metal residue. (by machine translation)
Process for Preparing Lubiprostone and Intermediate Therefor
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Paragraph 0159; 0160, (2017/05/12)
The present invention relates to a method for producing lubiprostone and an intermediate product used therefor. According to the present invention, the selective introduction of a protecting group onto corey lactone diol enables the production of lubiprostone in an efficient and economical way.