74123-81-2

Basic information

• Product Name: 1-(1,3-dimethyl-4-phenyl-1H-pyrazol-5-yl)-3-phenylurea
• Synonyms: 1-(1,3-dimethyl-4-phenyl-1H-pyrazol-5-yl)-3-phenylurea
• CAS NO: 74123-81-2
• Molecular Weight: 306.367
• Mol File: 74123-81-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(1,3-dimethyl-4-phenyl-1H-pyrazol-5-yl)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,3-dimethyl-4-phenyl-1H-pyrazol-5-yl)-3-phenylurea(74123-81-2)
• EPA Substance Registry System: 1-(1,3-dimethyl-4-phenyl-1H-pyrazol-5-yl)-3-phenylurea(74123-81-2)

Safety Data

• Hazardous Substances Data: 74123-81-2(Hazardous Substances Data)

Upstream product

• 103-71-9 phenyl isocyanate 
• 3524-32-1 5-Amino-1,3-dimethylpyrazole 
• 36198-21-7 1-(4-bromo-1,3-dimethyl-1H-pyrazol-5-yl)-3-phenylurea 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

The Suzuki-Miyaura Cross-Coupling Reaction of Halogenated Aminopyrazoles: Method Development, Scope, and Mechanism of Dehalogenation Side Reaction

The efficient Suzuki-Miyaura cross-coupling reaction of halogenated aminopyrazoles and their amides or ureas with a range of aryl, heteroaryl, and styryl boronic acids or esters has been developed. The method allowed incorporation of problematic substrates: aminopyrazoles bearing protected or unprotected pyrazole NH, as well as the free amino or N-amide group. Direct comparison of the chloro, bromo, and iodopyrazoles in the Suzuki-Miyaura reaction revealed that Br and Cl derivatives were superior to iodopyrazoles, as a result of reduced propensity to dehalogenation. Moreover, the mechanism and factors affecting the undesired dehalogenation side reaction were revealed.