74149-25-0

Basic information

• Product Name: 4,4-DIETHOXY-2-BUTYN-1-AL
• Synonyms: 4,4-DIETHOXY-2-BUTYN-1-AL;ACETYLENEDICARBALDEHYDE MONODIETHYLACETAL;4,4-Diethoxy-2-butynal.;4,4-DIETHOXY-2-BUTYN-1-AL 97%;4,4-Diethoxy-2-butyn-1-al,97%;4,4-diethoxybut-2-ynal
• CAS NO: 74149-25-0
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.18
• Mol File: 74149-25-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 73-74 °C (4 mmHg)
• Flash Point: 82.9°C
• Appearance: /
• Density: 1.0887 (rough estimate)
• Vapor Pressure: 0.186mmHg at 25°C
• Refractive Index: 1.442-1.444
• Storage Temp.: 0-6°C
• CAS DataBase Reference: 4,4-DIETHOXY-2-BUTYN-1-AL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIETHOXY-2-BUTYN-1-AL(74149-25-0)
• EPA Substance Registry System: 4,4-DIETHOXY-2-BUTYN-1-AL(74149-25-0)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 74149-25-0(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

InChI:InChI=1/C8H12O3/c1-3-10-8(11-4-2)6-5-7-9/h7-8H,3-4H2,1-2H3

Upstream product

• 3975-08-4 1,1,4,4-tetraethoxy-2-butyne 
• 18350-44-2 4,4-diethoxy-but-2-yn-1-ol 
• 10160-87-9 Propiolaldehyde diethyl acetal 
• 68-12-2 N,N-dimethyl-formamide 
• 122-51-0 orthoformic acid triethyl ester 
• 14444-77-0 diethyl phenyl orthoformate 

Downstream Products

• 136057-45-9 5-Diethoxymethyl-2-[2-thioxo-1-p-tolyl-eth-(Z)-ylidene]-[1,3]dithiole-4-carbaldehyde 
• 332411-76-4 1-(2-nitrophenyl)-4,5-diformyl[1,2,3]triazole 
• 124744-14-5 4,4-Diethoxy-but-2-ynylamine 
• 84071-80-7 2-Diethoxymethyl-6-[(E)-1-methyl-3-(2,6,6-trimethyl-cyclohex-1-enyl)-allyl]-thiopyran-4-one 
• 84071-79-4 (E)-1,1-Diethoxy-7-methyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-non-8-ene-2,5-diyn-4-one 

Relevant articles and documents

Synthesis of butanoic acid 4,4'-[(4E, 6Z, 9Z-pentadecatrien-2-ynylidene)]-bis with leukotriene-like activity: Novel acetylenic acetals and dithioacetals as antagonists of leukotriene-C4

A selective exchange reaction of a symmetrical acetal with protected cysteine readily provided two hemi-thioacetals related to leukotriene-E4. Use of acetylene-bis-(diethyl acetal) led to a facile synthesis of the title compound. Its correspond

Aminomethylpyrimidines as allosteric enhancers of the GABAB receptors

The present invention relates to compounds of formula whereinX is —S— or —NH—; R3/R4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7 membered ring, which optionally contains in addition to the N-atom one additional heteroatom selected from the group consisting of O, S and N, and wherein the ring is optionally substituted by hydroxy, lower alkyl, lower alkoxy, —NR2, —CONR2, —CO-lower alkyl or benzyl; or R3/R4 form together with the N-atom to which they are attached a heterocyclic ring system, containing two or three rings and which optionally contains one or two additional heteroatoms selected from the group consisting of N and O and which has no more than 20 carbon atoms; and R, R1, R2, and R5 are as defined herein and to pharmaceutically suitable acid addition salts thereof. It has been found that the compounds of the invention are active on the GABAB receptor and therefore are useful for the treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, psychosis, panic disorder, posttraumatic stress disorders and gastro-intestinal disorders.

Synthese regioselective par voie organometallique d'amines primaires propargyliques γ-fonctionnelles et applications

Reactive organozincs obtained from allylic and propargylic bromides regioselectively react with the N-trimethylsilylaldimine prepared in situ from the diethylmonoacetal of acetylenedicarbaldehyde and lead to unsatured γ-functional primary amines which possess many synthetic uses.