741703-34-4Relevant articles and documents
Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists
Gavai, Ashvinikumar V.,Vaz, Roy J.,Mikkilineni, Amarendra B.,Roberge, Jacques Y.,Liu, Yalei,Lawrence, R. Michael,Corte, James R.,Yang, Wu,Bednarz, Mark,Dickson Jr., John K.,Ma, Zhengping,Seethala, Ramakrishna,Feyen, Jean H. M.
, p. 5478 - 5482 (2005)
A 3D quantitative structure-activity relationship study for inhibition of calcium-sensing receptor in the aryloxypropanolamine series predicted that these molecules adopt a U-shaped conformation with pi-stacking between the two aromatic rings. This hypoth