74184-29-5Relevant articles and documents
Antibody-catalyzed oxidation of Δ9-tetrahydrocannabinol
Brogan, Andrew P.,Eubanks, Lisa M.,Koob, George F.,Dickerson, Tobin J.,Janda, Kirn D.
, p. 3698 - 3702 (2007)
Marijuana abuse continues to plague society and the lack of effective treatments warrants concern. Catalytic antibodies capable of oxidatively degrading the major psychoactive component of marijuana, Δ9- tetrahydrocannabinol (Δ9-THC), are presented. The antibodies generate reactive oxygen species from singlet oxygen (1O 2*), using riboflavin (vitamin B2) and visible light as the 1O2*source. Cannabitriol was identified as the major degradation product of this reaction, demonstrating the ability of an antibody to catalyze a complex chemical transformation with therapeutic implications for treating marijuana abuse.