74185-31-2

Basic information

• Product Name: 2-Ethynyl Benzoic Acid ethyl ester
• Synonyms: 2-Ethynyl Benzoic Acid ethyl ester;ethyl 2-ethynylbenzoate
• CAS NO: 74185-31-2
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174
• Mol File: 74185-31-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Ethynyl Benzoic Acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethynyl Benzoic Acid ethyl ester(74185-31-2)
• EPA Substance Registry System: 2-Ethynyl Benzoic Acid ethyl ester(74185-31-2)

Safety Data

• Hazardous Substances Data: 74185-31-2(Hazardous Substances Data)

Usage

General Description

2-Ethynyl Benzoic Acid ethyl ester, also known as ethyl 2-ethynylbenzoate, is a chemical compound with the molecular formula C11H8O2. It is a clear, colorless liquid that is commonly used in the pharmaceutical industry as a reagent and intermediate in the synthesis of various compounds. This chemical has also been studied for its potential applications in the field of organic electronics and as a building block for the synthesis of functional materials. It is important to handle this compound with care, as it may have potential health and environmental hazards.

Upstream product

• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 110166-76-2 ethyl 2-((trimethylsilyl)ethynyl)benzoate 
• 1829-28-3 ethyl 2-iodobenzoate 

Downstream Products

• 74185-33-4 2-((Z)-2-Methylselanyl-vinyl)-benzoic acid ethyl ester 
• 74185-36-7 2-((Z)-2-Methyltellanyl-vinyl)-benzoic acid ethyl ester 
• 74185-32-3 2-((Z)-2-Methylselanyl-vinyl)-benzoic acid 
• 74185-35-6 2-((Z)-2-Methyltellanyl-vinyl)-benzoic acid 
• 1215119-95-1 (Z)-1-(2-ethoxycarbonylphenyl)-4-chlorobut-3-en-1-yne 
• 1208108-45-5 C₂₁H₂₃ClN₄O₅ 

Relevant articles and documents

Synthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block

A novel fluoroalkyl iodide was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. We demonstrated its applicability in a metal-free photocatalytic ATRA reaction to synthesize valuable fluoroalkylated vinyl iodides and proved the straightforward transformability of the products in cross-coupling chemistry to obtain conjugated systems.

Cobalt(II)-based Metalloradical Activation of 2-(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation

A new catalytic method for the denitrogenative transannulation/cyclopropanation of in-situ-generated 2-(diazomethyl)pyridines is described using a cobalt-catalyzed radical-activation mechanism. The method takes advantage of the inherent properties of a CoIII-carbene radical intermediate and is the first report of denitrogenative transannulation/cyclopropanation by a radical-activation mechanism, which is supported by various control experiments. The synthetic benefits of the metalloradical approach are showcased with a short total synthesis of (±)-monomorine.