7421-40-1

Basic information

• Product Name: Carbenoxolone disodium
• Synonyms: (3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID 3-HEMISUCCINATE) DISODIUM SALT;CARBENOXOLONE DISODIUM SALT;CARBENOXOLONE SODIUM;18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt;20-beta)-3-bet;3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal;3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium;disodiumglycyrrhetinylsuccina
• CAS NO: 7421-40-1
• Molecular Formula: C34H48Na2O7
• Molecular Weight: 614.72
• EINECS: 231-044-0
• Product Categories: Miscellaneous;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;OPTAFLEXX
• Mol File: 7421-40-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 687.4oC at 760 mmHg
• Flash Point: 211.6oC
• Appearance: /
• Vapor Pressure: 1.06E-20mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Methanol (Slightly), Water (Slightly)
• PKA: pKa1 4.18; pKa2 5.52(at 25℃)
• Water Solubility: Soluble in water to 100 mM.
• Stability: Hygroscopic
• CAS DataBase Reference: Carbenoxolone disodium(CAS DataBase Reference)
• NIST Chemistry Reference: Carbenoxolone disodium(7421-40-1)
• EPA Substance Registry System: Carbenoxolone disodium(7421-40-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: RK0250000
• Hazardous Substances Data: 7421-40-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 7421-40-1 differently. You can refer to the following data:
1. Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.
2. Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative
3. beta-adrenergic agonist, growth stimulant

General Description

Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.

Biological Activity

Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.

references

[1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.[2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.

InChI:InChI=1/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23-,24-,27+,30+,31-,32-,33+,34+;;/m0../s1