74267-27-9 Usage
Description
CALCIUM IONOPHORE II is a chemical compound that functions as a calcium ionophore, which means it facilitates the transport of calcium ions across cell membranes. This property makes it a valuable tool in various scientific and medical applications, particularly in the study and manipulation of cellular processes involving calcium ions.
Uses
Used in Research and Diagnostic Applications:
CALCIUM IONOPHORE II is used as a research tool for studying intracellular calcium measurements. It aids in understanding the role of calcium ions in various cellular processes and signaling pathways, which is crucial for advancing our knowledge of cell biology and related fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, CALCIUM IONOPHORE II is used as a component in drug development and testing. Its ability to modulate calcium ion levels can be harnessed to develop new therapeutic agents targeting conditions related to calcium dysregulation, such as certain cardiovascular and neurological disorders.
Used in Biotechnology:
CALCIUM IONOPHORE II is also utilized in biotechnology for applications like cell fusion and genetic engineering. By manipulating calcium ion levels, it can induce cell fusion, which is an essential technique in the production of hybrid cells and the development of new cell lines with desired characteristics.
Purification Methods
Recrystallise it from Me2CO. It forms 1:2 and 1:3 metal/ligand complexes with Mg2+ and Ca2+ ions, respectively, and induces selectivity in membranes for Ca2+ over Mg2+ by a factor of ca 104. [Pretsch et al. Helv Chim Acta 63 191 1980, Simon & Carafoli Methods Enzymol 56 439 1977.]
Check Digit Verification of cas no
The CAS Registry Mumber 74267-27-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,2,6 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 74267-27:
(7*7)+(6*4)+(5*2)+(4*6)+(3*7)+(2*2)+(1*7)=139
139 % 10 = 9
So 74267-27-9 is a valid CAS Registry Number.
InChI:InChI=1/C28H48N2O3/c31-27(29(23-13-5-1-6-14-23)24-15-7-2-8-16-24)21-33-22-28(32)30(25-17-9-3-10-18-25)26-19-11-4-12-20-26/h23-26H,1-22H2
74267-27-9Relevant articles and documents
16. Ionophore vom Typ der 3-Oxapentadiamide
Pretsch, Erno,Ammann, Daniel,Osswald, Hans F.,Guggi, Marc,Simon, Wilhelm
, p. 191 - 196 (1980)
A series of lipophilic 3-oxapentane diamides were prepared and their selectivity in membranes was studied.N,N,N',N'-Tetracyclohexyl-3-oxapentane diamide forms 1:2- and 1:3-metal/ligand-complexes with Mg(2+) and Ca(2+) respectively and induces a selectivity in membranes for Ca(2+) over Mg(2+) by a factor of about 10E4.
