74274-66-1

Basic information

• Product Name: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• Synonyms: 1,8-naphthyridine-3-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
• CAS NO: 74274-66-1
• Molecular Formula: C₁₆H₁₉FN₄O₃
• Molecular Weight: 334.3455
• Mol File: 74274-66-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 540.7°C at 760 mmHg
• Flash Point: 280.8°C
• Density: 1.36g/cm³
• Vapor Pressure: 1.6E-12mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(74274-66-1)
• EPA Substance Registry System: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid(74274-66-1)

Safety Data

• Hazardous Substances Data: 74274-66-1(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 79286-73-0 1-ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-1,8-naphthyridine-3-carboxylic acid 
• 50-00-0 formaldehyd 
• 64-18-6 formic acid 
• 74011-58-8 enoxacine 
• 87938-98-5 C₁₉H₂₃N₆O₄⁽¹⁺⁾*F₆P^(1-) 
• 87939-04-6 7-(4-Acetyl-piperazin-1-yl)-1-ethyl-6-nitro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 87938-96-3 7-(4-Acetyl-piperazin-1-yl)-6-amino-1-ethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 54132-41-1 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 56654-05-8 ethyl 7-chloro-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 82671-13-4 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 84233-60-3 ethyl 7-(4-acetyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 87939-09-1 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8-naphthyridine-3-carboxylic acid 

Relevant articles and documents

N-methyl enoxacin aldehyde thiosemicarbazone derivatives as well as preparation method and application thereof

The invention discloses N-methyl enoxacin aldehyde thiosemicarbazone derivatives as well as a preparation method and an application thereof. The derivatives have the general structural formula shown in a formula I in the specification, wherein a substituent group R is H atom or hydrocarbonyl containing 1-5 carbon atoms. According to the N-methyl enoxacin aldehyde thiosemicarbazone derivatives, three advantageous pharmacophores including fluoronaphthalene quinacridone frameworks, imine-containing Schiff base and thiourea are spliced, so that the antitumor activity of the novel compound is improved and the toxic and side effects on normal cells are reduced. The derivatives can serve as an antitumor active substance for development of an antitumor drug with a brand-new structure.

N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative, preparation method and applications thereof

The invention discloses a N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative, a preparation method and applications thereof, wherein the chemical structure general formula represented by the following formula I is used, and in the formula I, Ar is a benzene ring or a substituted benzene ring or a furan ring or a pyridine ring. According to the present invention, the N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative achieves the combination of the four pharmacophores such as the naphthyridinone skeleton, the amide, the rhodanine and alpha,beta-unsaturated ketone so as to increase the anti-tumor activity of the new compound and reduce the toxic-side effects on normal cells, such that the N-methyl enoxacin (rhodanine unsaturated ketone) amide derivative can be adopted as the anti-tumor active substance so as to develop the anti-tumor drug having the completely-new structure.

Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof

This invention relates to 1,8-naphthyridine compounds of the formula STR1 wherein X is a halogen atom especially fluorine atom, R1 is an ethyl group or a vinyl group, and R2 is a hydrogen atom or a lower alkyl group, their salts and processes for the preparation of them. The 1,8-naphthyridine compounds and their salts are useful as antibacterial agents and intermediates thereof.