7433-32-1

Basic information

• Product Name: L-2-Aminoadipamic Acid
• Synonyms: L-2-Aminoadipamic Acid
• CAS NO: 7433-32-1
• Molecular Formula: C₆H₁₂N₂O₃
• Molecular Weight: 160.17
• Product Categories: Aliphatics;Amino Acids & Derivatives
• Mol File: 7433-32-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 173-175°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• CAS DataBase Reference: L-2-Aminoadipamic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: L-2-Aminoadipamic Acid(7433-32-1)
• EPA Substance Registry System: L-2-Aminoadipamic Acid(7433-32-1)

Safety Data

• Hazardous Substances Data: 7433-32-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Glutamine

Upstream product

• 1239710-21-4 methyl (2S)-5-cyano-2-(trichloromethylcarbonylamino)pentanoate 
• 108312-38-5 N^α,N^ε-di-tert-butyloxycarbonyl-L-lysine 2,2,2-trichloroethyl ester 
• 97347-28-9 Boc-Lys(Boc)-Otert-Bu 
• 97347-40-5 N^α,N^ca-diBoc-L-2-aminoadipamic acid tert-butyl ester 
• 108312-35-2 N^α,N^ca-di-tert-butyloxycarbonyl-L-homoglutamine 
• 42533-25-5 Tosyl-L-α-amino-adipinsaeure-8-amid 

Downstream Products

• 1118-90-7 L-homoglutamic acid 

Relevant articles and documents

Synthesis method of (S)-2, 6-diamino-5-oxohexanoic acid

The invention relates to a synthetic method of (S)-2, 6-diamino-5-oxohexanoic acid. The method mainly solves the technical problem of large-scale production of (S)-2, 6-diamino-5-oxohexanoic acid. The synthesis method comprises the following steps: reacting L-2-amino adipic acid with 9-fluorenylmethyl-N-succinimido carbonate in a mixed solution of water and acetone to generate a compound 1; under the catalysis of p-toluenesulfonic acid, reacting the compound 1 with paraformaldehyde in a toluene solution to generate a compound 2; reacting the compound 2 with di-tert-butyl dicarbonate, pyridine and ammonium carbonate in an ethyl acetate solution at room temperature to generate a compound 3; and reacting the compound 3 with lithium hydroxide in a mixed solution of ethanol and water to generate a target compound 4. As a derivative of (S)-2-amino adipic acid, (S)-2, 6-diamino-5-oxo hexanoic acid has become an important intermediate for the synthesis of alpha-amino adipic acid peptide.

Chemical Conversion of L-α,ο-Diamino Acids to L-ο-Carbamoyl-α-amino Acids by Ruthenium tetroxide Oxidation

Ruthenium tetroxide oxidation of N,C-protected derivatives of L-2,4-diaminobutyric acid, L-ornitine and L-lisine was carried out two-phase conditions and the corresponding imides, formed through the oxidation of the methylene adjacent to the ο-amino group, were obtained in good yields.Removal of the protecting groups from the products gave L-asparagine, L-glutamine and L-2-aminoadipic acid 6-amide, respectively.Thus the first chemical conversion of L-α,ο-diamino acids into the corresponding L-ο-carbamoyl-α-amino acids without racemization has been established.L-2-Aminoadipic acid 6-amide was further converted to L-2-aminoadipic acid by acid hydrolysis.This represents a convenient method for the synthesis of L-2-aminoadipic acid starting from L-lisine.Keywords - oxidation; ruthenium tetroxide; L-α-amino acid synthesis; N-protecting group; ruthenium tetroxide; L-α,ο-diamino acid; L-ο-carbamoiyl-α-amino acid; L-2-aminoadipicacid