74345-31-6Relevant articles and documents
OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE
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Page/Page column 129, (2010/12/31)
Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
Efficient generation of a trisporoid library by combination of synthesis and biotransformation
Schachtschabel, Doreen,Boland, Wilhelm
, p. 1366 - 1372 (2007/10/03)
(Chemical Equation Presented) Trisporic acids and their biosynthetic precursors represent a family of powerful fungal pheromones and morphogenetic factors. A highly flexible synthetic protocol is described that (i) provides rapid access to nonfunctionaliz
SYNTHESIS AND PLANT GROWTH INHIBITORY ACTIVITIES OF (+)- AND (-)-(2Z,4E)-5-(1',2'-EPOXY-2',6',6'-TRIMETHYLCYCLOHEXYL)-3-METHYL-2,4-PENTADIENOIC ACID
Oritani, Takayuki,Yamashita, Kyohei
, p. 1909 - 1912 (2007/10/02)
Chiral (+)- and (-)-enantiomers of (2Z,4E)-5-(1',2'-epoxy-2',6',6'-trimethylcyclohexyl)-3-methyl-2,4-pentadienoic acid have been synthesized from the chiral epoxy alcohols (+)- and (-)-1',2'-dihydro-1',2'-epoxy-β-ionone, which were prepared by Katsuki-Sharpless'asymmetric epoxidation of β-cyclogeraniol.The (+)-enantiomer showed strong inhibitory activity in a rice seedling and lettuce germination assay, whereas the (-)-enantiomer was 103 times less active. - Key Word Index - Plant growth inhibitor; absolute configuration; relationship between enantiomers and biological activity; rice seedling growth; lettuce seed germination; abscisic acid analogue; (2Z,4E)-5-(1',2'-epoxy-2',6',6'-trimethylcyclohexyl)-3-methyl-2,4-pentadienoic acid.