74375-17-0

Basic information

• Product Name: 2-(4-chloro-phenyl)-3-methylquinazolin-4(3H)-one
• Synonyms: 2-(4-chloro-phenyl)-3-methylquinazolin-4(3H)-one
• CAS NO: 74375-17-0
• Molecular Weight: 270.718
• Mol File: 74375-17-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-(4-chloro-phenyl)-3-methylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chloro-phenyl)-3-methylquinazolin-4(3H)-one(74375-17-0)
• EPA Substance Registry System: 2-(4-chloro-phenyl)-3-methylquinazolin-4(3H)-one(74375-17-0)

Safety Data

• Hazardous Substances Data: 74375-17-0(Hazardous Substances Data)

Upstream product

• 7099-88-9 4-chlorophenylglyoxylic acid 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 6258-66-8 (4-chlorophenyl)methanethiol 
• 88-67-5 2-Iodobenzoic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 58084-22-3 2-iodo-N-methyl-benzamide 
• 123-39-7 N-Methylformamide 
• 118-48-9 isatoic anhydride 
• 104-88-1 4-chlorobenzaldehyde 
• 106-43-4 para-chlorotoluene 
• 119072-55-8 tert-butylisonitrile 
• 1679-18-1 4-Chlorophenylboronic acid 
• 104-86-9 4-chlorobenzylamine 
• 74-89-5 methylamine 

Relevant articles and documents

Direct synthesis of quinazolinones via the carbon-supported acid-catalyzed cascade reaction of isatoic anhydrides with amides and aldehydes

A novel catalytic system is reported for the construction of quinazolinones via the carbon-supported acid-catalyzed cascade coupling of isatoic anhydrides with amides and aldehydes. Subsequent selective hydrosilylation of the quinazolinones using a hydrogen-transfer strategy was also explored to provide dihydroquinazolines with structural diversity. The developed methodology proceeds with a broad substrate scope, excellent functional group tolerance, and utilizes a reusable catalyst and air as a green oxidant.

An efficient transition-metal-free route to quinazolin-4(3H)-onesvia2-aminobenzamides and thiols

An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction ofo-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step.

Synthetic method of quinazolinone derivatives

The invention discloses a method for synthesizing quinazolinone derivatives, belonging to the technical field of organic synthesis. According to the preparation method, isatoic anhydride or derivatives thereof, aldehyde compounds and inert amide are used as raw materials and are subjected to one-step synthesis treatment to prepare the quinazolinone derivatives; synthesis steps are simple, raw materials are non-toxic, cheap and easy to obtain, and the synthesis method has the advantages of good functional group compatibility and high atom economy, and has the potential in large-scale one-step preparation of the quinazolinone derivatives.