74443-35-9

Basic information

• Product Name: BIS-(2,6-DIMETHYL-PHENYL)-AMINE
• Synonyms: BIS-(2,6-DIMETHYL-PHENYL)-AMINE
• CAS NO: 74443-35-9
• Molecular Formula: C₁₆H₁₉N
• Molecular Weight: 225.33
• Mol File: 74443-35-9.mol
• Article Data: 38

Chemical Properties

• Melting Point: 97-99 °C
• Boiling Point: 327.7±11.0 °C(Predicted)
• Appearance: /
• Density: 1.021±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.28±0.50(Predicted)
• CAS DataBase Reference: BIS-(2,6-DIMETHYL-PHENYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS-(2,6-DIMETHYL-PHENYL)-AMINE(74443-35-9)
• EPA Substance Registry System: BIS-(2,6-DIMETHYL-PHENYL)-AMINE(74443-35-9)

Safety Data

• Hazardous Substances Data: 74443-35-9(Hazardous Substances Data)

Usage

General Description

BIS-(2,6-DIMETHYL-PHENYL)-AMINE is an organic chemical compound with the molecular formula C14H17N. It is a type of aromatic amine and is commonly used in the synthesis of various polymers and materials. This chemical is often employed as an intermediate in the production of dyes, pharmaceuticals, and agricultural chemicals. BIS-(2,6-DIMETHYL-PHENYL)-AMINE has potential applications in the production of antioxidants, stabilizers, and UV absorbers for plastics and rubber products. It is important to handle this chemical with care, as prolonged or high-level exposure can have harmful effects on human health.

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Relevant articles and documents

N-Heterocyclic Carbene Palladium(II) Amine Complexes: The Role of Primary Aryl- or Alkylamine Binding and Applications in the Buchwald-Hartwig Amination Reaction

N-heterocyclic carbene-palladium(II) amine complexes bearing primary aryl- or alkylamines were synthesized. The prepared complexes were characterized by single crystal X-ray diffraction as well as NMR spectroscopy. These complexes exhibited good catalytic activities for the Buchwald-Hartwig amination reaction of aryl chlorides to afford arylated anilines under mild conditions. All reactions were carried out in air and all starting materials were used as supplied without purification. 21 expected coupling products were obtained in moderate to high yields under optimum conditions.

Synthesis of N-heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides

Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand have been obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes is an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enrich the chemistry of NHCs and give an alternative catalyst for the coupling of challenging while cost-low aryl chlorides.

Well-Designed N-Heterocyclic Carbene Ligands for Palladium-Catalyzed Denitrative C-N Coupling of Nitroarenes with Amines

The C-N bond formation is one of the fundamental reactions in organic chemistry, because of the widespread presence of amine moieties in pharmaceuticals and biologically active compounds. Palladium-catalyzed C-N coupling of haloarenes represents one of the most efficient approaches to aromatic amines. Nitroarenes are ideal alternative electrophilic coupling partners, since they are inexpensive and readily available. The denitration and cross-coupling using nitroarenes as the electrophilic partners is challenging, because of the low reactivity of the Ar-NO2 bond toward oxidative addition. We report here the C-N coupling of nitroarenes and amines using palladium/5-(2,4,6-triisopropylphenyl)imidazolylidene[1,5-a]pyridines as the catalyst. The ligands are readily available from commercial chemicals. The reaction shows broad substrate scope and functional group tolerance. The method is applicable to both aromatic and aliphatic amines, and many secondary and tertiary aromatic amines bearing various functional groups were obtained in high yields.