74500-56-4

Basic information

• Product Name: 2-Pentanol, 5-(triphenylmethoxy)-, (2S)-
• CAS NO: 74500-56-4
• Molecular Formula: C24H26O2
• Molecular Weight: 346.469
• Mol File: 74500-56-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Pentanol, 5-(triphenylmethoxy)-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentanol, 5-(triphenylmethoxy)-, (2S)-(74500-56-4)
• EPA Substance Registry System: 2-Pentanol, 5-(triphenylmethoxy)-, (2S)-(74500-56-4)

Safety Data

• Hazardous Substances Data: 74500-56-4(Hazardous Substances Data)

Upstream product

• 58879-34-8 (S)-5-tosyloxypentan-4-olide 
• 544-97-8 dimethyl zinc(II) 
• 136424-06-1 4-triphenylmethoxybutanal 
• 626-95-9 (2S)-2-methylbutane-1,4-diol 
• 76-83-5 trityl chloride 
• 20705-40-2 (cyclohexyloxy)triphenylmethane 
• 626-95-9 1,4-Pentanediol 
• 206882-28-2 C₂₄H₂₄O₂ 
• 78646-25-0 4-dimethylamino-1-N-(triphenylmethyl)pyridinium chloride 

Downstream Products

• 626-95-9 1,4-Pentanediol 
• 76-83-5 trityl chloride 
• 38257-95-3 6-(triphenylmethyloxy)-1-hexanol 
• 104784-02-3 (R)-1-<(triphenylmethyl)oxy>pentan-4-ol 
• 1392409-30-1 (4R,7R,10R,E)-4,7-dihydroxy-10-methyl-3,4,7,8,9,10-hexahydro-2H-oxecin-2-one 
• 1392409-11-8 (R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate 
• 93929-68-1 (1R,2S,4S)-2-<(6S)-t-butyldimethylsilyloxy-1-heptynyl>-4-(2-methoxyethoxymethoxy)-1-cyclopentylmethyl benzyl ether 
• 74500-59-7 (4S)-4-[tert-butyl(dimethyl)silyl]oxypentyl 4-methylbenzenesulfonate 
• 20350-15-6 (+)-brefeldin A 
• 104871-09-2 4-((tert-butyldimethylsilyl)oxy)pentyl-4-methylbenzenesulfonate 
• 765-38-8 (S)-2-methylpyrrolidine 
• 774-91-4 (S)-1-benzyl-2-methylpyrrolidine 
• 258331-61-2 (4S)-4-{[1-(tert-butyl)-1,1-diphenylsilyl]oxy}pentan-1-ol 
• 258331-78-1 tert-Butyl-((S)-1-methyl-4-trityloxy-butoxy)-diphenyl-silane 

Relevant articles and documents

Indium-mediated cleavage of the trityl group from protected alcohols and diols

The reaction of primary, secondary, allylic and benzylic trityl ethers with indium powder in MeOH/NH4Cl led to reductive cleavage of the trityl-oxygen bond, affording the corresponding alcohols in good to excellent yield under very mild reaction conditions. The detritylation process could successfully be extended to mono and detritylated diols. This methodology represents a new and efficient detritylation procedure under mild reaction conditions.

Convergent syntheses of 3,6-dihydroxydec-4-enolides

The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki-Hiyama-Kishi reaction in the key cyclization to generate the 6R stereocenter.

SYNTHESIS OF THE PROPIONATES OF (2R,8R)- AND (2RS,8R)-8-METHYL-2-DECANOL, THE ATTRACTANTS OF THE WESTERN CORN ROOTWORM

The propionate of (2R,8R)-8-methyl-2-decanol, (2R,8R)-1, an attractant of the western corn rootworm, Diabrotica virgifera Le Conte, has been prepared by a synthetic route in which enantiomerically pure methyl hydrogen (R)-3-methylglutarate, (R)-2, and (S)-glutamic acid, (S)-3, have been used as chiral precursors.In this convergent synthesis, (R)-2 and (S)-3 have been stereospecifically converted into (R)-1-bromo-3-methylpentane, (R)-4, and (R)-1,4-pentanediol, (R)-5, respectively.An analogous synthetic scheme has been followed to prepare biologically active (2RS, 8R)-1 starting from (R)-4 and racemic 5.