7453-13-6 Usage
Description
[1-(Chloromethyl)-2-chloroethoxy]trimethylsilane, also known as TMSCMCOCl, is a chemical compound with the molecular formula C7H17Cl2OSi. It is a colorless liquid that is soluble in organic solvents and water. [1-(Chloromethyl)-2-chloroethoxy]trimethylsilane is known for its ability to introduce a chloromethyl group and a chloroethoxy group in organic molecules, making it a versatile building block in chemical reactions. TMSCMCOCl is highly reactive and should be handled with care, as it is a strong irritant to the skin, eyes, and respiratory system.
Uses
Used in Pharmaceutical Synthesis:
[1-(Chloromethyl)-2-chloroethoxy]trimethylsilane is used as a reagent for the synthesis of various pharmaceuticals. Its ability to introduce a chloromethyl group and a chloroethoxy group in organic molecules makes it a valuable building block in the development of new drugs.
Used in Agrochemical Synthesis:
In the agrochemical industry, [1-(Chloromethyl)-2-chloroethoxy]trimethylsilane is used as a reagent for the synthesis of agrochemicals. [1-(Chloromethyl)-2-chloroethoxy]trimethylsilane's versatility in introducing specific functional groups into organic molecules aids in the creation of effective and targeted agrochemical products.
Used in Organic Synthesis:
[1-(Chloromethyl)-2-chloroethoxy]trimethylsilane is used as a reagent in organic synthesis for a wide range of applications. Its capacity to introduce chloromethyl and chloroethoxy groups into organic molecules allows for the development of various organic compounds with specific properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 7453-13-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,5 and 3 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7453-13:
(6*7)+(5*4)+(4*5)+(3*3)+(2*1)+(1*3)=96
96 % 10 = 6
So 7453-13-6 is a valid CAS Registry Number.
7453-13-6Relevant articles and documents
Synthesis of Diethyl 2-(Trimethylsiloxy)-alkanephosphonates from Epoxides and Diethyl Trimethylsilyl Phosphite
Azuhata, Toshio,Okamoto, Yoshiki
, p. 916 - 917 (1983)
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Dynamic kinetic resolution of epichlorohydrin via enantioselective catalytic ring opening with TMSN3. Practical synthesis of aryl oxazolidinone antibacterial agents
Schaus, Scott E.,Jacobsen, Eric N.
, p. 7937 - 7940 (2007/10/03)
The dynamic kinetic resolution of racemic epichlorohydrin has been achieved via enantioselective asymmetric ring opening with TMSN3 catalyzed by the (salen)Cr(III)N3 complex 1. The resulting 3-azido-1-chloro-2-trimethylsiloxypropane product was obtained in high enantiomeric purity and incorporated into the synthesis of U-100592, a representative from a class of highly-promising aryl oxazolidinone antibacterial agents.
NEW METHODS FOR THE SYNTHESIS OF ALKOXYSILANES, AND SOME OF THEIR PROPERTIES
Krolevets, A. A.,Antipova, V. V.,Popov, A. G.,Adamov, A. V.
, p. 2023 - 2030 (2007/10/02)
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