74530-56-6 Usage
Description
TERT-BUTYL-4-CHLORO-3-OXOBUTANOATE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its chemical structure, which includes a tert-butyl group, a chloro substituent, and a 3-oxobutanoate moiety. TERT-BUTYL-4-CHLORO-3-OXOBUTANOATE plays a significant role in the development of essential drugs, particularly in the field of antibiotics.
Uses
Used in Pharmaceutical Industry:
TERT-BUTYL-4-CHLORO-3-OXOBUTANOATE is used as a synthetic reagent for the preparation of cephalosporin antibiotics and penicillin derivatives. Its role in the synthesis process is vital, as it contributes to the development of these life-saving drugs that are widely used to treat bacterial infections.
Additionally, TERT-BUTYL-4-CHLORO-3-OXOBUTANOATE is used as a reagent for the synthesis of Ethyl 4-Chloroacetoacetate, which is another important compound in the pharmaceutical industry. This application highlights the versatility of TERT-BUTYL-4-CHLORO-3-OXOBUTANOATE in contributing to the development of various pharmaceutical products.
Check Digit Verification of cas no
The CAS Registry Mumber 74530-56-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,5,3 and 0 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 74530-56:
(7*7)+(6*4)+(5*5)+(4*3)+(3*0)+(2*5)+(1*6)=126
126 % 10 = 6
So 74530-56-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H13ClO3/c1-8(2,3)12-7(11)4-6(10)5-9/h4-5H2,1-3H3
74530-56-6Relevant articles and documents
Lipase-catalyzed resolution of esters of 4-chloro-3-hydroxybutanoic acid: Effects of the alkoxy group and solvent on the enantiomeric ratio
Hoff, Bard Helge,Anthonsen, Thorleif
, p. 1401 - 1412 (2007/10/03)
Various lipases have been investigated for their potential use as catalysts for the resolution of esters of 4-chloro-3-hydroxybutanoic acid via transesterification in organic solvents. Rhizomucor miehei lipase was found to be the most efficient lipase, with the enantiomeric ratio (E) being dependent upon of the nature of the alkoxy group of the ester and the resolution medium. Higher E-values were obtained when transesterification was performed in benzene or carbon tetrachloride than was the case in hexane. In mixtures of benzene and hexane the trend in E-values followed a linear relationship.