7455-77-8

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-
• Synonyms: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-;2-(4-chlorophenyl)quinazolin-4-ol;2-(4-chlorophenyl)-4(1H)-quinazolinone;2-(4-CHLOROPHENYL)QUINAZOLIN-4(3H)-ONE
• CAS NO: 7455-77-8
• Molecular Formula: C₁₄H₉ClN₂O
• Molecular Weight: 256.68706
• Mol File: 7455-77-8.mol
• Article Data: 181

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-(7455-77-8)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-(7455-77-8)

Safety Data

• Hazardous Substances Data: 7455-77-8(Hazardous Substances Data)

Upstream product

• 52962-92-2 2-(4-Chlorobenzamido)benzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 104655-42-7 2-(4-chlorophenyl)-3,4-dihydro-5H-1,3,4-benzotriazepin-5-one 
• 74-11-3 para-chlorobenzoic acid 
• 153172-72-6 4-chloro-N-(2-cyanophenyl)benzamide 
• 63002-70-0 2-(4-chlorophenyl)-3-aminoquinazolin-4(3H)-one 
• 623-03-0 4-Cyanochlorobenzene 
• 134-20-3 2-carbomethoxyaniline 
• 118-48-9 isatoic anhydride 
• 10345-77-4 2-nitro-N,N-diethylbenzamide 
• 122-01-0 4-chloro-benzoyl chloride 
• 118-92-3 anthranilic acid 
• 18600-52-7 2-(4-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

Access to 2-Arylquinazolin-4(3H)-ones through Intramolecular Oxidative C(sp3)?H/N?H Cross-Coupling Mediated by I2/DMSO

A novel approach for the synthesis of 2-arylquinazolin-4(3H)-ones was developed. A series of title compounds were obtained with good functional group tolerance and good yields by I2/DMSO-mediated intramolecular oxidative cross-coupling of 2-(benzylamino)benzamides to form C=N double bonds. This method was applicable for gram-scale synthesis. A proposed reaction pathway based on some control experiments was also provided.

N^N^O hydrazone capped pincer type palladium complex catalysed construction of quinazolinones from alcohols

New Pincer type Pd(II) complex [Pd(NNO)(PPh3)] (1) prompted synthesis of quinazolinones via dehydrogenative coupling of readily accessible alcohols, and o-aminobenzamide is described. A diverse range of quinazolinones has been synthesized efficiently with good to excellent yields employing low catalyst loading (0.5 mol%) under the aerobic condition without any additives/oxidants. A plausible mechanism for the construction of quinazolinones has been proposed via cyclic aminal intermediate. Large-scale synthesis attests to the productiveness of the current strategy.

A magnetically retrievable copper ionic liquid nanocatalyst for cyclooxidative synthesis of 2-phenylquinazolin-4(3: H)-ones

In the present work, we report the design and fabrication of a copper-containing ionic liquid supported magnetic nanocatalyst via a convenient and straightforward synthetic approach for the formation of 2-phenylquinazolin-4(3H)-ones using o-aminobenzamide and benzaldehydes as the reaction partners. The successful formation and properties of the as-prepared catalyst have been thoroughly investigated using diverse physico-chemical techniques including FT-IR, XRD, FE-SEM, TEM, ICP, VSM, BET and TGA. Using this nanocatalytic system, a variety of 2-phenylquinazolin-4(3H)-ones are synthesized in excellent yields with operational ease and short reaction times in an environmentally preferable solvent under open air and without using any external oxidizing agent. Besides, the catalyst possessed facile magnetic recoverability and remarkable reusability for six consecutive runs without any appreciable decrease in the catalytic efficiency.