745818-78-4

Basic information

• Product Name: (4R,5S)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-4-hydroxy-3,3-dimethyldihydrofuran-2(3H)-one
• Synonyms: (4R,5S)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-4-hydroxy-3,3-dimethyldihydrofuran-2(3H)-one
• CAS NO: 745818-78-4
• Molecular Weight: 308.375
• Mol File: 745818-78-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4R,5S)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-4-hydroxy-3,3-dimethyldihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-4-hydroxy-3,3-dimethyldihydrofuran-2(3H)-one(745818-78-4)
• EPA Substance Registry System: (4R,5S)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-4-hydroxy-3,3-dimethyldihydrofuran-2(3H)-one(745818-78-4)

Safety Data

• Hazardous Substances Data: 745818-78-4(Hazardous Substances Data)

Upstream product

• 745818-77-3 (5R)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-3,3-dimethylfuran-2,4(3H,5H)-dione 
• 745818-72-8 ethyl 7-(benzyloxy)-5-hydroxy-2,2-dimethyl-3-oxoheptanoate 
• 745818-75-1 (5R)-5-[(1S)-3-(benzyloxy)-1-hydroxypropyl]-3,3-dimethylfuran-2,4(3H,5H)-dione 
• 745818-73-9 (E)-ethyl 7-(benzyloxy)-2,2-dimethyl-3-oxohept-4-enoate 
• 19790-60-4 3-Benzyloxypropanal 
• 597-04-6 ethyl 2,2-dimethyl-3-oxobutanoate 

Downstream Products

• 1253891-04-1 (4R,5R)-5-((S)-3-(benzyloxy)-1-methoxypropyl)-4-(tert-butyldimethylsilyloxy)-3,3-dimethyldihydrofuran-2(3H)-one 
• 745818-83-1 (4R,5R)-5-{(1S)-2-[(4R,5R,6S)-2-ethyl-6-{(1R)-2-[(4-methoxybenzyl)oxy-1-methylethyl]-5-methyl-1,3,2-dioxaborinan-4-yl}-1-methoxyethyl]}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one 
• 745818-84-2 (4R,5R)-5-{(1S,3R,4R,5S,6R)-3,5-dihydroxy-1-methoxy-7-[(4-methoxybenzyl)oxy]-4,6-dimethylheptyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one 
• 745818-82-0 (4R,5R)-5-{(1S,3R,4R,6R)-3-hydroxy-1-methoxy-7-[(4-methoxybenzyl)oxy]-4,6-dimethyl-5-oxoheptyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one 
• 745818-85-3 (4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one 

Relevant articles and documents

Towards the total synthesis of calyculin C: Preparation of the C 9-C25 spiroketal-dipropionate unit

An asymmetric synthesis of the C9-C25 spiroketal fragment of calyculin C is described. Key steps include two crotylation reactions using successively BrowN′s reagent and (Z)-crotyltrifluorosilane for the formation of the anti, anti, anti stereotetrad, ynone formation by a Pd-catalyzed coupling of a thiol ester with a terminal alkyne and a double intramolecular hetero-Michael addition for the stereoselective construction of the spiroketal framework.

Studies towards the synthesis of the C(9)-C(20) lactone-dipropionate fragment of calyculin C

In this paper we describe the synthesis of a diastereomer of the C(9)-C(20) dipropionate-lactone fragment of Calyculin C. A short and enantioselective synthesis of the key intermediate 2 has been developed. This intermediate will play a critical role also