74585-21-0

Basic information

• Product Name: 4-methyl-3-(p-tolyl)oxazol-2(3H)-one
• Synonyms: 4-methyl-3-(p-tolyl)oxazol-2(3H)-one
• CAS NO: 74585-21-0
• Molecular Weight: 189.214
• Mol File: 74585-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methyl-3-(p-tolyl)oxazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-3-(p-tolyl)oxazol-2(3H)-one(74585-21-0)
• EPA Substance Registry System: 4-methyl-3-(p-tolyl)oxazol-2(3H)-one(74585-21-0)

Safety Data

• Hazardous Substances Data: 74585-21-0(Hazardous Substances Data)

Upstream product

• 622-58-2 p-Tolylisocyanate 
• 116-09-6 hydroxy-2-propanone 

Downstream Products

• 67627-60-5 3b,10,11b-trimethyl-1-(p-tolyl)-3b,4-dihydro-1H-dioxazolo[3,4-a:5',4'-c]quinoline-2,6(3aH,11bH)-dione 
• 74585-26-5 4,4'-Dimethyl-3,3'-di-p-tolyl-4,5-dihydro-3H,3'H-[4,5']bioxazolyl-2,2'-dione 

Relevant articles and documents

Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones

A mild and practical method for the construction of heterocycles from N-substituted 2-oxazolones through cascade, BF3·Et2O/H2O-catalyzed reactions involving iminium ion generation and trapping by external or internal olefinic and aryl moieties is described. Mechanistic and computational studies revealed the strong protic acid HBF4as the initiating catalyst for these cascade reactions. Providing access to novel molecular diversity, these processes may facilitate chemical biology studies, drug discovery efforts and natural products synthesis.